血清IL-8、IL-10的浓度变化与冠心病的关系 |
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引用本文: | 沈琴,张劲松,陈波,王连生.血清IL-8、IL-10的浓度变化与冠心病的关系[J].现代保健,2009(17):10-11. |
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作者姓名: | 沈琴 张劲松 陈波 王连生 |
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作者单位: | 南京医科大学第一附属医院,210029 |
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摘 要: | 目的探讨白介素-8(IL-8)与白介素-10(IL-10)在不稳定型心绞痛及急性心肌梗死患者血清中的变化规律。方法检测不稳定型心绞痛、急性-t3肌梗死患者及正常对照者各30例血中IL-8、IL-10浓度并进行比较。结果不稳定型心绞痛组、急性心肌梗死组及正常对照组患者血中IL-8分别为(156.9±44.2)pg/ml、(171.3±49.6)pg/ml和(68.9±43.3)pg/ml,不稳定型心绞痛组及急性心肌梗死组高于正常对照组,差异有显著性(P〈0.01),不稳定型心绞痛组与急性心肌梗死组无明显差异。不稳定型心绞痛组、急性心肌梗死组及正常对照组血中IL-10分别为(178.5±54.5)pg/ml、(234.8±79.8)pg/ml、(59.3±21.6)pg/ml,不稳定型心绞痛组及急性心肌梗死组高于正常对照组,差异有显著性(P〈0.01),不稳定型心绞痛组与急性心肌梗死组无明显差异。结论IL-8、IL-10可能参与了冠心病的发生发展,其血清浓度的显著升高可能与动脉粥样斑块的不稳定相关。
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关 键 词: | 白介素-8 白介素-10 不稳定型心绞痛 急性心肌梗死 酶联免疫测定法 |
The relationship between the changed concentration of IL - 8 and IL - 10 and coronary heart disease |
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Institution: | SHEN Qin,ZHANG Jin - song, CHEN Bo, WANG Lian - sheng(The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China) |
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Abstract: | Objective To explore the changed rule of interleukin -8(IL -8) and interleukin -10(IL- 10) in tb, patients with unstable angina pectoris or with acute myocardial infarction. Methods The concentrations of IL - 8 and IL - 1L were measured in 30 patients with unstable angina pectoris and 30 patients with acute myocardial infarction, compared with 30 cases in healthy control group. Results The concentrations of IL - 8 in the groups of unstable angina pectoris and acute myocardial infarction were ( 156.9 ±44.2 ) pg/ml and ( 171.3 ± 49.6 ) pg/ml respectively, higher than that in the group of healthy control group which was (68.9 ±43.3) pg/ml(P 〈0.01 ). Moreover, the concertration of serum IL - 10 in the groups of unstable angina pectoris and acute myocardial infarction were ( 178.5 ±54.5 ) pg/ml and ( 234.8±79.8 ) pg/ml respectively, higher than that in the group of healthy control group which was (59.3 ± 21.6 ) pg/ml( P 〈 0.01 ). Conclusion The concentrations of serum IL -8 and IL - 10 in the patients with unstable angina pectoris or with acute myocardial infarction were higher than healthy people. |
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Keywords: | Interleukin - 8 Interleukin - 10 Unstable angina pectoris Acute myocardial infarction Enzyme linked immunosorbent assay |
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