血浆B型利钠肽水平与慢性心功能不全的相关性研究

目的探讨血浆B型利钠肽（BNP）与慢性心功能不全的相关性。方法将根据Framingham诊断标准纳入的65例慢性心功能不全患者按NYHA分级，并采用Triage快速定量测定仪检测患者血浆BNP值。结果患者BNP水平从心功能Ⅰ～Ⅳ级各组逐渐升高，心功能Ⅱ～Ⅳ级组均高于心功能Ⅰ级组（P〈0．05），心功能Ⅳ级组高于心功能Ⅱ级组和Ⅲ级组（P〈0．05），心功能Ⅱ级组与Ⅲ级组间BNP水平无湿著性差异（P〉0．05）。结论BNP可作为评价心脏功能状态的一个常规检查，并可作为慢性心功能不全诊断和分级的客观指标。

Study on the relation between brain natriuretic peptide level and chronic heart dysfunction

Objective To study the relation between plasma BNP level change and degree of chronic heart dysfunction. Methods 65 patients were diagnosed to chronic heart dysfunction by Framingham criteria, and were divided into 4 groups according to NYHA. Plasma BNP level were detected by Triage rapid measure machine. Results BNP level was gradually increasing from class Ⅰ group to class Ⅳ group. BNP levels in class Ⅱ ,Ⅲ,Ⅳ group were higher than that in class Ⅰ group （ P 〈 0. 05 ）. BNP level in class Ⅳ group was significantly higher than that in class Ⅱ ,Ⅲ group （ P 〈 0.05 ）. There was no significant difference between class Ⅱ and Ⅲ groups （ P 〉 0. 05 ）. Conclusion BNP may be a routine method to evaluate heart function and be a objective index to diagnose and evaluate prognosis in heart dysfunction.