| 伴有胃肠动力障碍的重症急性胰腺炎大鼠结肠肠肌间神经丛一氧化氮合成酶神经元的变化 |
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| 引用本文： | 刘颖,林中,胡琼花,郑清华. 伴有胃肠动力障碍的重症急性胰腺炎大鼠结肠肠肌间神经丛一氧化氮合成酶神经元的变化[J]. 第三军医大学学报, 2010, 32(3) |
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| 作者姓名： | 刘颖 林中 胡琼花 郑清华 |
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| 作者单位： | 桂林,桂林医学院附属医院消化科,广西壮族自治区,541001 |
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| 摘 要： | 目的观察伴有胃肠动力障碍的重症急性胰腺炎(severe acute pancreatitis,SAP)大鼠结肠肠神经系统(enteric nervous system,ENS)肌间神经丛一氧化氮合成酶(nitric oxide synthase,NOS)神经元的变化,以探讨SAP胃肠动力障碍的神经机制。方法20只SD大鼠随机均分为假手术组和SAP组,逆行胰胆管穿刺逆行注射5%牛磺胆酸钠制作SAP模型。检测腹部X线、小肠推进比,胰腺病理评分。制作肌间神经丛全层标本,应用双重免疫荧光染色法观察NOS神经元的形态及占总神经元的百分比。结果与假手术组相比,SAP组大鼠肠管明显扩张,SAP组小肠推进比显著降低(P<0.01),胰腺病理评分明显增高(P<0.01),NOS神经元胞体大而染色深,结间束NOS神经纤维粗大,NOS神经元比例为(40.74±5.15)%明显高于假手术组(P<0.01)。结论结肠肌间丛NOS神经元表达增多可能是大鼠SAP胃肠动力障碍神经机制之一。
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| 关 键 词： | 重症急性胰腺炎 胃肠动力障碍 肠神经系统 肌间神经丛 一氧化氮合成酶神经元 |
Change of nitric oxide synthase neurons in colonic myenteric plexus of rats with severe acute pancreatitis complicated by gastrointestinal dysmotility |
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| Liu Ying,Lin Zhong,Hu Qionghua,Zheng Qinghua. Change of nitric oxide synthase neurons in colonic myenteric plexus of rats with severe acute pancreatitis complicated by gastrointestinal dysmotility[J]. Acta Academiae Medicinae Militaris Tertiae, 2010, 32(3) |
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| Authors: | Liu Ying Lin Zhong Hu Qionghua Zheng Qinghua |
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| Affiliation: | Department of Gastroenterology;Affiliated Hospital of Guilin Medical University;Guilin;Guangxi Zhuang Autonomous Region;541001;China |
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| Abstract: | Objective To study the nervous mechanism underlying gastrointestinal dysmotility by observing the change of nitric oxide synthase(NOS) neurons in colonic myenteric plexus of the enteric nervous system(ENS)in rats with severe acute pancreatitis(SAP)complicated by gastrointestinal dysmotility.Methods Twenty Sprague Dawley rats were randomly divided into sham operation group and SAP group.A SAP model was induced by retrograde cholangiopancreatography-guided injection of 5% sodium taurocholate.Abdominal X-ray f... |
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| Keywords: | severe acute pancreatitis gastrointestinal dysmotility enteric nervous system myenteric plexus nitric oxide synthase neuron |
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