| 川芎嗪对环核苷酸磷酸二酯酶的抑制作用 |
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| 引用本文： | 吴光玉,文允镒,陈孟勤.川芎嗪对环核苷酸磷酸二酯酶的抑制作用[J].基础医学与临床,1990(1). |
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| 作者姓名： | 吴光玉 文允镒 陈孟勤 |
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| 作者单位： | 中国医学科学院基础医学研究所生理研究室
(吴光玉，文允镒)，中国医学科学院基础医学研究所生理研究室(陈孟勤) |
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| 摘 要： | 实验利用Ca~(2+)依赖性环核苷酸磷酸二酯酶(PDE)测定方法,观察川芎嗪拮抗钙调素(CaM)的作用。当川芎嗪浓度大于0.3mM时,能明显抑制CaM激活的PDE活性,其半抑制浓度(IC_(50))为6.5mM。在浓度大于4mM时,川芎嗪开始抑制PDE的基础活性。咪唑能减弱川芎嗪对PDE的抑制作用。
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| 关 键 词： | 川芎嗪 钙调素 钙调素拮抗剂 环核苷酸磷酸二酯酶 |
The Inhibitory Effect of Ligustrazine on Activity of Cyclic Nucleotide Phosphodiesterase |
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| Wu Guangyu Wen Yunyi Chen Mengchin.The Inhibitory Effect of Ligustrazine on Activity of Cyclic Nucleotide Phosphodiesterase[J].Basic Medical Sciences and Clinics,1990(1). |
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| Authors: | Wu Guangyu Wen Yunyi Chen Mengchin |
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| Abstract: | Using the assay system of Ca2+-dependent cyclic nucleotide phosphodieste-rase (PDE), we observed the antagonistic effects of ligusterazine on calmodu-lin (CaM) . The activity of CaM-stimulated PDE was apparently inhibited by Iigusterazine at a concentration of more than 0.3mM and the IC50 was 6.5 mM. At a concentration greater than 4 mM tke drug also inhibited the basal activity of PDE. Irnmidazole reduced the suppressive effect of ligustrazine on the activity of PDE. |
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| Keywords: | ligustrazine calmodulin calmodulin antagonist cyclic nucleotide phosphodiesterase |
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