Motility of leukemic cells in collagen gel related to immunological phenotype in childhood acute lymphoblastic leukemia |
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| Authors: | P H Hogeman A J Veerman D R Huismans C H Van Zantwijk P D Bezemer |
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| Affiliation: | Department of Pediatrics, Free University Hospital, Amsterdam, The Netherlands. |
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| Abstract: | Motility of leukemic cells was measured in a three-dimensional collagen matrix assay. Leukemic cells from 16 children with acute lymphoblastic leukemia (ALL) and normal peripheral blood lymphocytes (NPBL) from 6 healthy volunteers, were allowed to migrate into this collagen matrix for 48 h at 37 degrees C. NPBL migrated much further (300-600 micron) than leukemic cells (0-200 micron). Among the leukemic cases, only common ALL and one case of null ALL showed some migration (0-200 micron). T-All cells did not migrate at all under the circumstances of this experiment. |
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