| Abstract: | Responses of the mesenteric microvessels of rats to application and intravenous injection of bradykinin were studied in acute experiments using intravital microscopy. No clear bioelectric response of the smooth-muscle cells of the microvessels to local application of bradykinin could be found in electrophysiological experiments. In another series of experiments the dynamics of vasomotor activity were studied after the same treatment by the split-image method. The response of the microvessels to bradykinin application was shown to vary in character depending principally on whether the preparation was being applied for the first or subsequent time. It is suggested that bradykinin acts on the mesenteric microvessels through the intermediary of other vasoactive substances.Laboratory of General Pathology and Experimental Therapy, Institute of General Pathology and Pathological Physiology, Academy of Medical Sciences of the USSR, Moscow. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 81, No. 3, pp. 259–261, March, 1976. |
