33例复发性腹膜后肉瘤的治疗及其预后

目的探讨复发性腹膜后肉瘤的治疗方法及其预后。方法回顾性分析１９７２年～１９９６年收治的３３例复发性腹膜后肉瘤的临床资料。结果１７例（５１５％）患者在首次复发时完整切除肿瘤;２、３、１例患者分别在首次、２次和３次复发时进行联合脏器切除。共１４例患者术后接受不同剂量的放疗和化疗。对２９例患者进行６个月至１２年的随访,其中１５例（５１７％）死亡,７例生存５年以上,２例生存１０年以上。１、３、５年生存率分别为８５７％,５４９％和４２３％。结论外科手术切除肿瘤是提高复发性肉瘤生存率最重要的手段,联合脏器切除能提高肿瘤完整切除率,对多次复发的肿瘤不应放弃手术机会,放疗和化疗对复发性肉瘤可起一定的控制作用。病理类型为高分化脂肪肉瘤者,预后优于患其他类型肉瘤者

Treatment and prognosis of 33 patients with recurrent retroperitoneal soft tissue sarcomas

Objective To investigate the treatment and the prognosis of patients with recurrent retroperitoneal soft tissue sarcomas. Method The clinical data of 33 patients, treated for recurrent retroperitoneal soft tissue sarcomas from 1972 to 1996 were analyzed retrospectively. Result Complete tumor resection was performed for 17 patients (51 5%) with tumor recurrence for the first time. 2,3,1 patients underwent multiple organs resection respectively when the sarcoma relapsed initially, secondly and thirdly. Fourteen patients were given adjuvant radiotherapy and chemotherapy postoperatively. Twenty nine patients were followed for up for 6 to 12 months. Fifteen (51 7%) of them died. Seven of them survived beyond 5 years and 2 over 10 years. The 1 , 3 , and 5 years survival rate was 85 7%, 54 9% and 42 3% respectively. Conclusion Surgery is effective in improving the survival rate of patients with recurrent retroperitoneal soft tissue sarcomas, including those with repeatedly recurrent sarcomas. Multiple organ resection could be beneficial to the curative resection rate. Adjuvant radiotherapy and chemotherapy might improve the local control of relapsed sarcomas to some extent.