Survival in familial and non-familial breast cancer by age and stage at diagnosis |
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| Affiliation: | 1. Department of Pathology, University of Utah Health Sciences Center, 1950 Circle of Hope, RM N3100, Salt Lake City, UT 84112, USA;2. AvanSciBio LLC, 1290 West 2320 South, Salt Lake City, UT 84119, USA;3. Counsyl, Inc., 180 Kimball Way, South San Francisco, CA 94080, USA;4. Wisconsin State Lab of Hygiene, University of Wisconsin-Madison, 465 Henry Mall, Madison, WI 53706, USA;5. ARUP Institute for Clinical and Experimental Pathology, 500 Chipeta Way, Salt Lake City, UT 84108, USA;6. ARUP Laboratories, 500 Chipeta Way, Salt Lake City, UT 84108, USA |
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| Abstract: | We aimed to compare the survival in familial and sporadic breast cancer (BC) patients who were diagnosed at an identical age and TNM stage. The Nationwide Swedish Family-Cancer Database including all Swedes born after 1931 and their biological parents, totalling >14.7 million individuals, was used. Hazard ratios (HRs) were calculated for women with BC in a first-degree relative (FDR) versus BC patients without positive family history. There was no difference in survival of familial BC patients who were diagnosed at higher TNM status or older age (>40) compared to sporadic BC cases diagnosed at the same late TNM stage. Young BC patients (age <40) in early stages had the worst survival when their FDR was diagnosed with single (HR: 2.0–3.7) or multiple (HR: 2.4–7.1) BC at any age. We concluded that there is no difference in survival of familial and non-familial BC patients who are diagnosed at higher TNM status or older ages (>40). Young familial BC patients (age <40), diagnosed at early stage, have the poorer survival compared to sporadic cases. Our results urge the need for identifying the underling genetic component for such a difference in survival of familial BC. |
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| Keywords: | Breast cancer Familial risk Survival |
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