Quality of life in elderly patients with localized breast cancer treated with radiotherapy. A prospective study |
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| Institution: | 1. Complejo Hospitalario de Navarra, Radiotherapeutic Oncology Department, Irunlarrea 3, 31008 Pamplona, Spain;2. Complejo Hospitalario de Navarra, Medical Oncology Department, Irunlarrea 3, 31008 Pamplona, Spain;3. Fundación Miguel Servet-NavarraBiomed, Red de Investigación en Servicios Sanitarios en Enfermedades Crónicas (REDISSEC), Irunlarrea 3, 31008 Pamplona, Spain;4. Instituto Salud Pública, CIBER Salud Pública, Leyre 3, 31003 Pamplona, Spain;1. Regional Center of Nuclear Medicine, University Hospital of Pisa, Pisa, Italy;2. Neurosurgery Unit, University Hospital of Pisa, Pisa, Italy;3. Health Physics Unit, Section of Medical Physics, University Hospital of Pisa, Pisa, Italy;4. Division of Pathology, University Hospital of Pisa, Pisa, Italy;5. Department of Nuclear Medicine, “S. Maria della Misericordia” Hospital, Rovigo, Italy;1. Section of Patient Centred Outcomes Research, Leeds Institute of Medical Research at St James’s, Faculty of Medicine and Health, University of Leeds, Leeds, UK;2. Leeds Institute of Health Sciences, Faculty of Medicine and Health, University of Leeds, Leeds, UK;3. School of Social Sciences, Beckett University, Leeds, UK;4. Department of Respiratory Medicine, Leeds Teaching Hospital Trust, Leeds, UK;5. Department of Clinical Oncology, Leeds Teaching Hospital Trust, Leeds, UK;6. Department of Thoracic Surgery, Leeds Teaching Hospital Trust, Leeds, UK;1. Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States;2. Procure Proton Therapy Center, Somerset, New Jersey 08873, United States;1. Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, The Netherlands;2. Department of Cardiothoracic Surgery, University of Groningen, University Medical Center Groningen, The Netherlands;3. Department of Respiratory Diseases, University of Groningen, University Medical Center Groningen, The Netherlands;4. Medical University of Vienna, Austria;1. Department of Psychiatry, University Hospital Jiménez Díaz Foundation, Spain;2. Department of Personality, Evaluation and Psychological Treatments, National University of Distance Education (UNED), Spain |
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| Abstract: | PurposeThere is a debate on the role of adjuvant Radiotherapy (RT) in elderly breast cancer patients.The aim is to study Quality of Life (QL) throughout the treatment and follow-up periods in early stages breast cancer patients who have started radiotherapy, and to compare the QL of axillary surgery groups.Methods173 patients, ≥65 years completed the EORTC QLQ-C30 and QLQ-BR23, and the Interview for Deterioration in Daily Living Activities in Dementia(IDDD) questionnaires three times throughout treatment and follow-up periods. Linear mixed effect models were used to evaluate longitudinal changes in QL, and whether these changes differed among axillary surgery groups.ResultsQL scores were high (>70/100 points) in most QL areas, with moderate limitations (>30) in sexual functioning and enjoyment, future perspective and global QL.In six areas there was a decline at the RT sessions end, that after 6 weeks was recovered. For three areas, there was an improvement in the follow-up measurement compared to the previous assessments. Changes in seven areas were <5 points.Axillary node dissection patients had a body image decrease (6 points) in the follow up period. The lymphadenectomy group had more fatigue (10 points, p = 0.078) than the other two axillary surgery groups.ConclusionsResults orientate towards good patients' adaptation to their disease and treatments, and to administering RT in early stages breast cancer patients. QL differences between the axillary surgery groups and in their evolutions were few but have appeared in key QL areas. |
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| Keywords: | Quality of life Breast cancer Elderly Radiotherapy EORTC RT"} {"#name":"keyword" "$":{"id":"kwrd0040"} "$$":[{"#name":"text" "_":"radiotherapy QL"} {"#name":"keyword" "$":{"id":"kwrd0050"} "$$":[{"#name":"text" "_":"quality of life ALND"} {"#name":"keyword" "$":{"id":"kwrd0060"} "$$":[{"#name":"text" "_":"axillary node dissection SLNB"} {"#name":"keyword" "$":{"id":"kwrd0070"} "$$":[{"#name":"text" "_":"sentinel node surgery |
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