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How we approach conservative treatment of retinoblastoma in South America in the era of local ocular treatments: A consensus of the Grupo America Latina de Oncologia Pediatrica (GALOP) |
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| Authors: | Juan Pablo López Garin Claudia Sampor Nathalia Grigorovski Alejandro Ceciliano Adriana Fandiño Diego Ossandon Verónica Perez Rafaela Caixeta Joaquim Caetano Aguirre Neto Sandra Alarcón Sonia Silva Luiz Teixeira Celia Gianotti Antoneli Clarissa Mattosinho Carlos Leal-Leal Guilherme Castela Flavio Requejo Jaume Catala Carla Macedo Guillermo L Chantada |
| Affiliation: | 1. Department of ophthalmology, Universidad de Chile, Santiago, Chile;2. Hematology-Oncology Service, Hospital de Pediatría SAMIC Juan P Garrahan, Buenos Aires, Argentina;3. Pediatric Oncology Service, Instituto Nacional do Cancer, INCA, Rio de Janeiro, Brazil;4. Interventional Neuroradiology, Hospital Universitario Austral, Pilar, Argentina;5. Ophthalmology Service, Clínica Alemana de, Santiago, Chile;6. Ophthalmology Service, Clínica Alemana de, Santiago, Chile Ophthalmology Service, Hospital San Juan de Dios, Santiago, Chile;7. Pediatric Oncology Service, Hospital Santa Casa, Belo Horizonte, Brazil;8. Ophthalmology Service, Hospital San Juan de Dios, Santiago, Chile;9. Pediatric Oncology Service, Instituto Nacional de Enfermedades Neoplasicas, INEN, Lima, Peru;10. Pediatric Oncology Service, Centro Hospitalar Universitário de Coimbra, Coimbra, Portugal;11. Ophthalmology Service, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Sao Paulo, Brazil;12. Pediatric Oncology, Universidade Nove de Julho, Sao Paulo, Brazil;13. Pediatric Oncology Service, Hospital Infantil Privado, Mexico City, Mexico;14. Ophthalmology Service, Hospital Sant Joan de Deu, Barcelona, Spain |
| Abstract: | Local therapies are increasingly used for ocular preservation in retinoblastoma. In middle-income countries, these techniques pose specific challenges mostly related to more advanced disease at diagnosis. The Grupo de America Latina de Oncología Pediátrica (GALOP) developed a consensus document for the management of conservative therapy for retinoblastoma. Intra-arterial chemotherapy (OAC) is the preferred therapy, except for those with less advanced disease or age younger than 6 months. OAC allowed for a reduction in the use of external beam radiotherapy in our setting. Intravitreal chemotherapy is the preferred treatment for vitreous seeding. Enucleation is the treatment of choice for eyes with advanced disease. |
| Keywords: | intra-arterial chemotherapy intra-vitreal chemotherapy retinoblastoma |