Complementary and alternative medicine for lowering blood lipid levels: A systematic review of systematic reviews |
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| Affiliation: | 1. Honorary Research Fellow, Plymouth University Peninsula Schools of Medicine and Dentistry, United Kingdom;2. National Center for Complementary and Alternative Medicine, Ministry of Health, Riyadh, Saudi Arabia;1. School of Health Professions, Murdoch University, Murdoch, Western Australia, Australia;2. SolarisCare Foundation, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia;3. Chancellery, Swinburne University of Technology, Hawthorn, Victoria, Australia;4. School of Medicine, University of Notre Dame Sydney, Darlinghurst, New South Wales, Australia;5. Calvary Health Care Sydney, Kogarah, New South Wales, Australia;6. Cunningham Centre for Palliative Care, Darlinghurst, New South Wales, Australia;7. Harry Perkins Institute for Medical Research, Nedlands, Western Australia, Australia;8. Centre for Medical Research, University of Western Australia, Crawley, Western Australia, Australia;9. Royal Perth Hospital, Perth, Western Australia, Australia;10. Centre for Nursing Research, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia;11. Department of Haematology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia;12. Faculty of Health and Medical Sciences, University of Western Australia, Crawley, Western Australia, Australia;1. Department of Family and Community Medicine, Faculty of Medicine, University of Jordan, Amman, Jordan;2. Department of Surgery, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey;3. Faculty of Medicine, Department of Biostatistics, Istanbul Medeniyet University, Istanbul, Turkey;4. Department of Biostatistics and Medical Informatics, Faculty of Medicine, Düzce University, Düzce, Turkey;5. Qatar University, College of Medicine, Population Medicine Department, Qatar;1. Faculty of Health, University of Technology Sydney, NSW, Australia;2. Centre for Cardiovascular and Chronic Care, University of Technology Sydney, NSW, Australia;3. Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, NSW, Australia;1. Klinik für Innere Medizin II, Universitätsklinikum Jena, Am Klinikum 1, 07747 Jena, Germany;2. Krebszentrum Nord, CCC, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Arnold-Heller-Straße 3, Haus 14, 24105 Kiel, Germany;3. Das Lebenshaus e.V. (House of Life), Untergasse 36, 61200 Wölfersheim, Germany |
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| Abstract: | BackgroundThe aim of this article is to summarize and critically evaluate the evidence from systematic reviews (SRs) of complementary and alternative medicine (CAM) for lowering blood lipid levels (BLL).MethodsEight electronic databases were searched until March 2016. Additionally, all the retrieved references were inspected manually for further relevant papers. Systematic reviews were considered eligible, if they included patients of any age and/or gender with elevated blood lipid levels using any type of CAM. We used the Oxman and AMSTAR criteria to critically appraise the methodological quality of the included SRs.ResultsTwenty-seven SRs were included in the analyses. The majority of the SRs were of high methodological quality (mean Oxman score = 4.81, SD = 4.88; and the mean AMSTAR score = 7.22, SD = 3.38). The majority of SRs (56%) arrived at equivocal conclusions (of these 8 were of high quality); 7 SRs (37%) arrived at positive conclusions (of these 6 were of high quality), and 2 (7%) arrived at negative conclusions (both were of high quality). There was conflicting evidence regarding the effectiveness of garlic; and promising evidence for yoga.ConclusionsTo conclude, the evidence from SRs evaluating the effectiveness of CAM in lowering BLL is predominantly equivocal and confusing. Several limitations exist, such as variety of doses and preparations, confounding effects of diets and lifestyle factors, or heterogeneity of the primary trials among others. |
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| Keywords: | Cardiovascular diseases Complementary and alternative medicine Systematic reviews Effectiveness |
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