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大肠癌患者血清CD147和MMP-2水平的变化及意义
引用本文:熊枝繁,李杰,曹仕琼,刘浩,赵志辉,李丽,李正英,吴燕茹,熊莉娜.大肠癌患者血清CD147和MMP-2水平的变化及意义[J].中国医师杂志,2008,10(4):478-480.
作者姓名:熊枝繁  李杰  曹仕琼  刘浩  赵志辉  李丽  李正英  吴燕茹  熊莉娜
作者单位:1. 华中科技大学同济医学院附属梨园医院消化内科,湖北,武汉,430077
2. 华中科技大学同济医学院附属梨园医院普外科
3. 华中科技大学同济医学院附属梨园医院检验科
4. 华中科技大学同济医学院附属梨园医院病理科
基金项目:湖北省卫生厅科研项目 
摘    要:目的检测细胞外基质金属蛋白酶诱导因子(EMMPRIN,又称CD147)和基质金属蛋白酶-2(MMP-2)在大肠癌血清中的水平,探讨其与大肠癌恶性程度、侵袭和转移的关系及其相互联系。方法应用酶联免疫吸附实验(ELISA)方法测定44例大肠癌、28例大肠息肉和36例健康对照者血清中CD147和MMP-2的水平。结果大肠癌患者组血清CD147(103.59±40.74)pg/ml和MMP-2(14.92±2.02)ng/ml水平明显高于大肠息肉组(66.27±16.91;10.96±1.71)和健康对照组(63.84±18.71;10.49±1.61)(P〈0.05),差异有统计学意义;大肠癌患者中伴转移组血清中CD147水平显著高于无转移组(P〈0.05),大肠癌患者低分化组血清中MMP-2水平显著高于高,中分化组(P〈0.05),大肠癌患者根治性手术组术后1个月CD147和MMP-2水平明显下降(P〈0.05),而姑息性手术组虽有下降但不显著(P〉0.05)。大肠癌患者血清CD147和MMP-2水平呈正相关(r=0.61,P〈0.05)。结论大肠癌患者血清CD147和MMP-2水平增高,与肿瘤的组织分化程度、转移、分期有关,动态观察血清CD147和MMP-2水平的变化可作为大肠癌的诊断、手术方法的选择、疗效评价及预后监测有意义的参考指标。

关 键 词:肠肿瘤  明胶酶A  抗原  CD

Serum CD147 and MMP-2 levels in patients with colorectal cancer and their significance
XiONG Zhi-fan,LI Jie,CAO Shi-qiong,LIU Hao,LIU Zhi-hui,LI Li,LI Zhen-yin,WU Yan-ru,XIONG Li-na.Serum CD147 and MMP-2 levels in patients with colorectal cancer and their significance[J].Journal of Chinese Physician,2008,10(4):478-480.
Authors:XiONG Zhi-fan  LI Jie  CAO Shi-qiong  LIU Hao  LIU Zhi-hui  LI Li  LI Zhen-yin  WU Yan-ru  XIONG Li-na
Institution:XIONG Zhi-fan, LI Jie, CAO Shi-qiong,LIU Hao, LIU Zhi-hui, LI Li, LI Zhen-yin, WU Yan-ru, XIONG Li-na( Department of Digestive Diseases, Liyuan Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, China)
Abstract:Objective To investigate the serum levels of CD147 and MMP-2 and the relationship between these proteins and colorectal tumor differentiation, Dukes stage. Methods Serum levels of CD147 and MMP-2 in 44 patients with colorectal carcinoma,28 polyp intestinal patients and 36 normal subjects were measured by ELISA. Results Serum levels of CD147(103.59±40.74pg/ml)and MMP-2(14.92±2.02ng/ml)in the cancer patients were significantly higher than those of the polyp intestinal(66.27±16.91;10:96±1.71)and normal control(63.84±18.71;10.49±1.61)(P<0.05).The levels were associated with tumor differentiation and Dukes stage. Patients with poor differentiation had significantly higher levels of MMP-2 than those of patients with well differentiation. And Dukes C and D stage tumors had significantly higher levels of CD147 than Dukes A and B stage tumors(P<0.05).The levels of CD147 and MMP-2 declined remarkably after one month of radical operation. Conversely, it decreased illegibly after palliative operation. The serum levels of CD147were positively correlated with MMP-2 in patients with colorectal cancer. Conclusion Elevated CD147 and MMP-2 serum levels are associated with tumor differentiation, invasion, metastasis. Dynamic alterations of serum CD147 and MMP-2 may be used as the indicators of diagnosis, the choice of operative method and the judgment of prognosis in patients with colorectal cancer.
Keywords:Intestinal neoplasms  Gelatinase A  Antigens  CD
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