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Associations of APOE gene polymorphisms with bone mineral density and fracture risk: a meta-analysis |
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| Authors: | I. Peter M. D. Crosier M. Yoshida S. L. Booth L. A. Cupples B. Dawson-Hughes D. Karasik D. P. Kiel J. M. Ordovas T. A. Trikalinos |
| Affiliation: | (1) Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, 10029, USA;(2) Framingham State College, Framingham, MA, USA;(3) Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA;(4) Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA;(5) Framingham Heart Study, Framingham, MA, USA;(6) Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA, USA;(7) Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA |
| Abstract: | SummaryTo determine the association of the Apolipoprotein E (APOE) E4 gene polymorphism with bone mineral density (BMD) and fractures we conducted a meta-analysis of 17 reports. Despite lower trochanteric and lumbar BMD in APOE4 carriers, there is insufficient evidence to support a consistent association of APOE with bone health. |
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