Loss of Rh Antigen Activity Following the Action of Phospholipase A2 on Red Cell Stroma |
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| Authors: | N. C. Hughes-Jones Elizabeth J. Green and Valerie A. M. Hunt |
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| Affiliation: | MRC Experimental Haematology Unit, St. Mary's Hospital Medical School, London |
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| Abstract: | Abstract. The degradation of red cell stroma phospholipids by phospholipase A2 is accompanied by a concomitant fall in the activity of the Rh antigens, c, D and e. The action of phospholipase C on stroma also brings about a fall in D antigen activity. Anti-D bound to the red cells protects the D antigen from inactivation by phospholipase A2. |
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