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Antireproductive effect of the calcium channel blocker amlodipine in male rats.
Authors:S A Almeida  J M Teófilo  J A Anselmo Franci  L G Brentegani  T L Lamano-Carvalho
Affiliation:1. Faculty of Basic Medicine, MV Lomonosov Moscow State University, Moscow, Russia;2. Department of Translational Inflammation, Institute of Experimental Internal Medicine, Otto von Guericke University, Magdeburg, Germany;3. Division of Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden;1. Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, PR China;2. Department of Pathology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, PR China;3. Molecular and Pathological Diagnosis Center, Chongqing Medical University, Chongqing 400016, PR China
Abstract:The purpose of the present study was to investigate whether treatment of male rats with the calcium antagonist amlodipine, used in the treatment of hypertension and angina, interferes with the reproductive function of male rats. Amlodipine treatment (0.04 mg amlodipine besylate/rat/day for 30 days) decreased plasma follicle-stimulating hormone and testosterone but not luteinizing hormone or prolactin concentrations (measured by double-antibody radioimmuno-assay). A significant reduction (23%) was observed in sperm density (sperm suspension collected from the cauda epididymidis) as well as in the amount of mature spermatids (14%) and Sertoli cells (9%) counted in seminiferous tubule cross-sections (400 x magnification). The results reveal the deleterious effects of subacute amlodipine treatment on the reproductive function of male rats.
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