| Association of HIF—1α expression and cell apoptosis after traumatic brain injury in the rat |
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| 引用本文： | 于如同,高立达,等.Association of HIF—1α expression and cell apoptosis after traumatic brain injury in the rat[J].中华创伤杂志(英文版),2001,4(4):218-221. |
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| 作者姓名： | 于如同 高立达 |
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| 作者单位： | [1]DepartmentofNeurosurgery,AffiliatedHospitalofXuzhouMedicalCollege,Xuzhou221002 [2]DepartmentofNeurosurge,AffiliatedHospitalofXuzhouMedicalCollege,Xuzhou221002 |
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| 基金项目： | JiangsuProvinceTechnology AssociationFoundation (No .DJ995 0 1) |
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| 摘 要： | ＨＤｅｐａｒｔｍｅｎｔｏｆＮｅｕｒｏｓｕｒｇｅｒｙ ,ＡｆｆｉｌｉａｔｅｄＨｏｓｐｉｔａｌｏｆＸｕｚｈｏｕＭｅｄｉｃａｌＣｏｌｌｅｇｅ ,Ｘｕｚｈｏｕ 2 2 10 0 2 ,Ｃｈｉｎａ (ＹｕＲＴ)ＤｅｐａｒｔｍｅｎｔｏｆＮｅｕｒｏｓｕｒｇｅｒｙ ,ＷｅｓｔＣｈｉｎａＭｅｄｉｃａｌＵｎｉｖｅｒｓｉｔｙ ,Ｃｈｅｎｇｄｕ 6 10 0 41,Ｃｈｉｎａ (ＧａｏＬＤ ,ＪｉａｎｇＳ ,ＧｕａｎＰａｎｄＭａｏＢＹ)ＴｈｉｓｐｒｏｊｅｃｔｗａｓｇｒａｎｔｅｄｂｙＪｉａｎｇｓｕＰｒｏｖｉｎｃｅＴｅｃｈｎｏｌｏｇｙＡｓｓｏｃｉａｔｉｏｎＦｏｕｎ…
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| 关 键 词： | 颅脑损伤 细胞凋亡 低氧诱导因子－1α |
Association of HIF-1alpha expression and cell apoptosis after traumatic brain injury in the rat. |
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| YU Rutong,GAO Lida,JIANG Shu GUAN Peng and MAO Boyong.Association of HIF-1alpha expression and cell apoptosis after traumatic brain injury in the rat.[J].Chinese Journal of Traumatology(English Edition),2001,4(4):218-221. |
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| Authors: | YU Rutong GAO Lida JIANG Shu GUAN Peng and MAO Boyong |
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| Institution: | Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China. |
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| Abstract: | OBJECTIVE: To explore the expression of hypoxia inducible factor-1alpha (HIF-1alpha) and the correlation between HIF-1alpha and apoptosis after traumatic brain injury. METHODS: Using experimental traumatic brain injury in the rats, the expression of HIF-1alpha was studied by immunohistochemistry in cerebral tissue, apoptotic cell death was evaluated with TUNEL (transferase-mediated X-dUTP nick end labeling), and double-labeled immunohistochemistry and TUNEL methods were used to investigate the relationship between HIF-1alpha and apoptosis. RESULTS: There was remarkable difference in the expression of H IF-1alpha between the experimental groups and the control groups (P<0.01), in the experimental groups, the expression of HIF-1alpha at 48 hours was highest; the evidence of apoptotic cell death after experimental traumatic brain injury was found by TUNEL; the apoptotic percentage increased or decreased according to the changes of the positive expression of HIF-1alpha (r=0.99). CONCLUSIONS: The results suggest that secondary brain ischemia plays a crucial role in apoptotic cell death after traumatic brain injury; HIF-1alpha can prompt apoptotic cell death after experimental traumatic brain injury. |
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