血浆抵抗素浓度与脑外伤预后的相关性研究

目的:揭示脑外伤患者血浆抵抗素浓度,分析其与预后的相关性.方法:收集重型脑外伤患者作为脑外伤组,共108例.收集同期健康体检人群作为对照组,共40例.对照组静脉血体检时获得.脑外伤组静脉血在入院时获得.ELISA测定血浆抵抗素浓度,统计分析其与预后的相关性.结果:脑外伤患者入院后1个月内死亡28例(25.9%).脑外伤...

The Study on Relationship of Plasma Resistin Concentration with Prognosis of Patients with Traumatic Brain Injury

Objective To observe plasma resistin levels in patients with traumatic brain injury(TBI) and evaluate its correlation with outcome.Methods 108 consecutive patients with severe TBI and 40 age-and sex-matched healthy controls were enrolled into this study.Plasma samples were obtained on entry in healthy controls and on admission in the patients.Its concentration was measured by enzyme-linked immunosorbent assay.Results 28 patients(25.9%) died fromTBI in a month.Plasma resistin level in the patients(27.5±14.3) ng/ml was substantially higher than that of healthy controls(9.3±2.6)ng/ml(P<0.001) using T test.A multivariate analyses selected plasma resistin level as an independent predictor for 1-month mortality(OR=1.139,95%CI=1.051~1.242,P=0.001).Using pearson correlation coefficient,plasma resistin levels of patients were negatively associated with Glasgow coma scale scores on admission(r=-0.432,P<0.01).A receiver operating characteristic curve identified cutoff levels of plasma resistin level(29.5 ng/ml) that predicted 1-month mortality of patients with the high sensitivity(72.2%)and specificity values(68.5%).Conclusion Increased plasma resistin level is found after traumatic brain injury,in association with a poor clinical outcome.