血浆抵抗素浓度与脑外伤预后的相关性研究 |
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引用本文: | 柯欣,罗金明,杨辉,陈晓宇. 血浆抵抗素浓度与脑外伤预后的相关性研究[J]. 放射免疫学杂志, 2011, 24(6): 680-682 |
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作者姓名: | 柯欣 罗金明 杨辉 陈晓宇 |
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作者单位: | 台州市第一人民医院ICU,318020 |
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摘 要: | 目的:揭示脑外伤患者血浆抵抗素浓度,分析其与预后的相关性.方法:收集重型脑外伤患者作为脑外伤组,共108例.收集同期健康体检人群作为对照组,共40例.对照组静脉血体检时获得.脑外伤组静脉血在入院时获得.ELISA测定血浆抵抗素浓度,统计分析其与预后的相关性.结果:脑外伤患者入院后1个月内死亡28例(25.9%).脑外伤...
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关 键 词: | 抵抗素 脑外伤 预后 |
The Study on Relationship of Plasma Resistin Concentration with Prognosis of Patients with Traumatic Brain Injury |
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Affiliation: | Ke Xin,Luo Jin-ming,Yang Hui,et al. Intensive Care Unit,The First People’s Hospital of Taizhou,Taizhou(318020),China |
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Abstract: | Objective To observe plasma resistin levels in patients with traumatic brain injury(TBI) and evaluate its correlation with outcome.Methods 108 consecutive patients with severe TBI and 40 age-and sex-matched healthy controls were enrolled into this study.Plasma samples were obtained on entry in healthy controls and on admission in the patients.Its concentration was measured by enzyme-linked immunosorbent assay.Results 28 patients(25.9%) died fromTBI in a month.Plasma resistin level in the patients(27.5±14.3) ng/ml was substantially higher than that of healthy controls(9.3±2.6)ng/ml(P<0.001) using T test.A multivariate analyses selected plasma resistin level as an independent predictor for 1-month mortality(OR=1.139,95%CI=1.051~1.242,P=0.001).Using pearson correlation coefficient,plasma resistin levels of patients were negatively associated with Glasgow coma scale scores on admission(r=-0.432,P<0.01).A receiver operating characteristic curve identified cutoff levels of plasma resistin level(29.5 ng/ml) that predicted 1-month mortality of patients with the high sensitivity(72.2%)and specificity values(68.5%).Conclusion Increased plasma resistin level is found after traumatic brain injury,in association with a poor clinical outcome. |
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Keywords: | resistin traumatic brain injury prognosis |
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