胃癌浸润转移的螺旋CT征象与PTEN表达的相关性

目的:探讨胃癌螺旋CT(SCT)征象与磷酸酶基因(PTEN)表达之间的潜在联系,以及与临床病理的相关性.方法:选择进展期胃癌患者60例,术前一周进行SCT三期增强扫描,术后标本分别进行HE染色读片及免疫组化染色SP法检测PTEN表达.结果:SCT示浆膜侵犯判断的准确性为91.66%(55/60),淋巴结转移判断准确性为...

Correlation Between Spiral CT Signs and PTEN Expressionin Gastric Cancer Infiltration and Metastasis

Objective To evaluate the potential link between spiral CT(SCT) signs and PTEN expression in gastric cancer and the correlation with clinicopathology.Methods Sixty patients with advanced gastric cancer were selected.SCT three-phase enhanced scan was conducted on them a week before surgery.HE staining,smearing and SP immunohistochemical staining were conducted on specimens after surgery to detect PTEN expression.Results SCT showed the accuracy of determining serosal invasion was 91.66%(55/60),that of determining lymph node metastases was 78.95%(45/57),and that of determining distant metastases was 100%(4/4),of which,four patients with distant metastases combined with lymph node metastases.SCT diagnosis and pathological diagnosis of serosal invasion(T3 + T4) and lymph node metastasis(including distant metastasis) showed a good consistency(P values were 0.00013 and 0.00011,respectively).Diagnosed by SCT,the positive rate of PTEN expression in patients with no serosal invasion was 75.00%,significantly higher than that(27.08%) of patients with serosal invasion(P<0.05);that of patients with no lymph node metastasis was 100.00%,significantly higher than that(33.33%) of patients with lymph node metastasis(P<0.05);that of patients with no distant metastasis was 39.29%,and of 4 patients with distant metastasis,the two groups showed significant differences(P<0.05).Conclusion PTEN is an important biological indicator to predict the metastatic potential of gastric cancer cells.Gastric cancer patients who have low PTEN expression possessed a higher metastatic potential,while SCT signs is closely related to PTEN expression in tumor cells.Clinically,biological characteristics of gastric cancer can be speculated by SCT signs noninvasively,and thus a reasonable assessment is conducted on the invasion,metastasis and prognosis of gastric cancer to guide and develop rational treatment plans.