COPD患者治疗前后血清NO、NOS和GM-CSF检测的临床意义

目的：探讨了慢性阻塞性肺疾病（COPD）患者治疗前后血清NO、NOS和GM-CSF水平的变化及临床意义。方法：应用放射免疫分析和化学法对34例COPD患者进行了治疗前后血清NO、NOS和GM-CSF检测,并与35名正常健康人作比较。结果：COPD患者在治疗前血清NO、NOS和GM-CSF水平均非常显著地高于正常人组（P〈0.01）,经中西医结合治疗1个月后与正常人组比较仍有显著性差异（P〈0.05）。结论：NO、NOS和GM-CSF水平的测定,可适用为一种筛选方法,其变化可能以不同的方式参与了COPD的发病,此外,水平的检测还可以对了解病情、指导治疗具有重要的临床价值。

Clinical Significance of Determination of Serum NO,NOS and GM-CSF Levels After Treatment in Patients with Chronic Obstructive Pulmonary Disease (COPD)

Objective To observe the significance of changes of serum NO,NOS and GM-CSF levels after treatment in patients with COPD.Methods Serum NO,NOS(with chemistry) serum GM-CSF(with RIA) levels were measured both before and after treatment in 34 patients with COPD as well as in 35 normal controls.Results Before treatment the serum NO,NOS and GM-CSF levels were significantly higher than those in controls(P<0.01),after 1 month of treatment,the serum NO,NOS and GM-CSF levels though dropped markedly,remained apparently higher than those in controls(P<0.05).Conclusion Measurement of NO,NOS and GM-CSF were suitable to be used as a screening method.Besides,it could take part in the pathogenesis of COPD in various ways and the changes of these levels is clinically important.