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Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy
Authors:Chirag Krishna  Renzo G DiNatale  Fengshen Kuo  Raghvendra M Srivastava  Lynda Vuong  Diego Chowell  Sounak Gupta  Chad Vanderbilt  Tanaya A Purohit  Ming Liu  Emily Kansler  Briana G Nixon  Ying-Bei Chen  Vladimir Makarov  Kyle A Blum  Kyrollis Attalla  Stanley Weng  Michael L Salmans  A Ari Hakimi
Institution:1. Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;2. Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;3. Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;4. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;5. Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;6. Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;7. Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA;8. Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;9. Illumina, Inc., 5200 Illumina Way, San Diego, CA 92122, USA;10. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, NY 10065, USA;11. Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;12. Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH 44195, USA;13. Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA;14. National Center for Regenerative Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
Abstract:
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  • Keywords:renal cell carcinoma  single-cell RNA-sequencing  TCR sequencing  immunotherapy  tyrosine kinase inhibitors  tissue-resident  tumor-associated macrophages  pathology
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