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Three new steroidal saponins from Aspidistra letreae plants and their cytotoxic activities |
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| Authors: | Ho Duc Viet Hoang Hanh Nhu Thi Vo Hung Quoc Nguyen Khan Viet Pham Ty Viet Le Anh Tuan Van Phan Kiem Nguyen Hien Minh Morita Hiroyuki Nguyen Hoai Thi |
| Affiliation: | 1.Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen, Hue, Vietnam ;2.Faculty of Basic Science, Hue University of Agriculture and Forestry, Hue University, 102 Phung Hung, Hue, Vietnam ;3.Faculty of Chemistry, Hue University of Education, Hue University, 34 Le Loi, Hue, Vietnam ;4.Quang Tri Center of Science and Technology, Mientrung Inst. for Scientific Research, VAST, Dien Bien Phu, Dong Ha, Quang Tri, Vietnam ;5.Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam ;6.Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam ;7.Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan ; |
| Abstract: | Three new steroidal saponins, aspiletreins A–C (1–3), together with 2H-chromen-2-one (4), and α-tocopherol (5), were isolated from whole Aspidistra letreae plants collected in Vietnam. Their structures were elucidated by a combination of spectroscopic analyses, including 1D- and 2D-NMR, IR, and HRESIMS, and by comparison with the reported data in the literature. Compounds 1–3 exhibited moderate cytotoxicities against the LU-1, HeLa, MDA-MB-231, HepG2, and MKN-7 human cancer cell lines, with IC50 values ranging from 7.69?±?0.40 to 20.46?±?3.11 µM. |
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