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A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation
Authors:Gregory Lazarian  Shanye Yin  Elisa ten Hacken  Tomasz Sewastianik  Mohamed Uduman  Alba Font-Tello  Satyen H. Gohil  Shuqiang Li  Ekaterina Kim  Heather Joyal  Leah Billington  Elizabeth Witten  Mei Zheng  Teddy Huang  Mariano Severgnini  Valerie Lefebvre  Laura Z. Rassenti  Catherine Gutierrez  Catherine J. Wu
Affiliation:1. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA;2. INSERM, U978, Université Paris 13, Bobigny, France;3. Laboratoire d''Hématologie, APHP Hôpital Avicenne, Bobigny, France;4. Harvard Medical School, Boston, MA, USA;5. Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA;6. Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland;7. Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA;8. Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA;9. Broad Institute of MIT and Harvard, Cambridge, MA, USA;10. Department of Academic Haematology, University College London, London, UK;11. Translational Immunogenomics Lab, Dana-Farber Cancer Institute, Boston, MA, USA;12. Department of Leukemia, the University of Texas MD Anderson Cancer Center, Houston, TX, USA;13. Department of Pathology, Brigham and Women''s Hospital, Boston, MA, USA;14. Center for Immuno-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA;15. Moores Cancer Center, University of California, San Diego, USA;16. Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA, USA;17. Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;18. Department of Systems Biology, Beckman Research Institute, City of Hope National Comprehensive Cancer Center, Monrovia, CA, USA;19. Division of Hematology-Oncology, Department of Medicine, Moores Cancer Center, University of California, San Diego, USA;20. Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA;21. Department of Pathology, Brigham and Women''s Hospital, Boston, MA, USA;22. Department of Medicine, Brigham and Women''s Hospital, Boston, MA, USA
Abstract:
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  • Keywords:CLL  IKZF3  murine model  NF-κB  BCR signaling
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