Adherence to the MIND Diet and Risk of Breast Cancer: A Case-control Study |
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| Authors: | Vajiheh Aghamohammadi Asma Salari-Moghaddam Sanaz Benisi-Kohansal Mohsen Taghavi Leila Azadbakht Ahmad Esmaillzadeh |
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| Affiliation: | 1. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran;2. Department of Nutrition, Islamic Azad University Olum Tahghighat, Tehran, Iran;3. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran;4. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran;5. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran;1. Department of Surgical Oncology, Breast Disease Management Group, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India;2. Breast Disease Management Group, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India;3. Department of Pathology, Breast Disease Management Group, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India;4. Department of Radiation Oncology, Breast Disease Management Group, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India;1. Postgraduate Program of Tocogynecology, Botucatu Medical School, Sao Paulo State University, UNESP, Sao Paulo, Brazil;2. Nucleous of Mastology, Barretos Cancer Hospital, Sao Paulo, Brazil;3. Postgraduate Program of Oncology, Barretos Cancer Hospital, Sao Paulo, Brazil;4. Londrina Cancer Hospital, Parana, Brazil;5. Cancer Unit, Santa Casa de Misericórdia de Itapeva, Sao Paulo, Brazil;6. Oswaldo Cruz German Hospital, Sao Paulo, Brazil;7. FACISB School of Medicine, Sao Paulo, Brazil;1. Department of Medical Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;2. Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences, Shenzhen Center, Shenzhen, China;1. Department of Medicine and Surgery and Translational Medicine, “Sapienza” University of Rome, Radiotherapy Oncology, St Andrea Hospital, Rome, Italy;2. Department of Statistical Sciences, “Sapienza” University of Rome, Rome, Italy;3. Department of Clinical and Molecular Medicine, “Sapienza” University of Rome, Hearth Failure Unit, St Andrea Hospital, Rome, Italy;4. Department of Clinical and Molecular Medicine, “Sapienza” University of Rome, St Andrea Hospital, Rome, Italy;1. Department of Surgery, University Hospital of North Midlands, Stoke on Trent, UK;2. Department of Radiology, University Hospital of North Midlands, Stoke on Trent, UK;3. Department of Pathology, University Hospital of North Midlands, Stoke on Trent, UK;4. Department of Medicine, University of Keele, Staffordshire, UK;1. Magee-Womens Research Institute, Pittsburgh, PA;2. Integrative Systems Biology Program, University of Pittsburgh, Pittsburgh, PA;3. UPMC Department of Surgery, Pittsburgh, PA;4. Department of General Surgery, Selçuk University, Konya, Turkey;5. Department of Pathology, Selçuk University, Konya, Turkey;6. Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA;7. Women’s Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, PA;8. UPMC Hillman Cancer Center, Pittsburgh, PA;9. Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA;10. Institute for Precision Medicine, University of Pittsburgh Cancer Institute, Pittsburgh, PA |
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| Abstract: | IntroductionNo data are available on the association between adherence to the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet and breast cancer.Materials and MethodsThis population-based case-control study was conducted among women aged ≥ 30 years, who were residing in Isfahan, Iran. The study included 350 patients with newly diagnosed stage I to IV breast cancer, for whom in situ or invasive status of breast cancer was confirmed by physical examination, mammography, and pathologic verification. Controls were 700 age-matched apparently healthy individuals who were randomly selected from the general population. Dietary data were collected using a validated 106-item Willett-format, semi-quantitative dish-based food frequency questionnaire.ResultsAfter adjustment for age and energy intake, women in the top tertile of the MIND diet score had 60% lower odds of breast cancer than women in the bottom tertile (odds ratio [OR], 0.40; 95% confidence interval [CI], 0.29-0.55). In the fully adjusted model including body mass index, those with the greatest MIND diet scores had 50% lower chance of breast cancer (OR, 0.50; 95% CI, 0.34-0.72) than those with the lowest adherence to the MIND diet. Postmenopausal women with the greatest adherence to the MIND diet were less likely to have breast cancer than those in the bottom tertile (OR, 0.45; 95% CI, 0.30-0.66). In addition, we found a significant inverse association between adherence to the MIND diet and odds of breast cancer among normal-weight women (OR, 0.39; 95% CI, 0.25-0.60).ConclusionAdherence to the MIND diet was associated with a reduced chance of breast cancer in this case-control study. |
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| Keywords: | Breast neoplasms DASH diet Diet Iran Mediterranean diet |
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