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Critical repolarization gradients determine the induction of reentry-based torsades de pointes arrhythmia in models of long QT syndrome
Authors:Mathilde R. Rivaud  Jason D. Bayer  Matthijs Cluitmans  Jeanne van der Waal  Laura R. Bear  Bastiaan J. Boukens  Charly Belterman  Lisa Gottlieb  Fanny Vaillant  Emma Abell  Remi Dubois  Veronique M.F. Meijborg  Ruben Coronel
Affiliation:1. Department of Clinical and Experimental Cardiology, Amsterdam UMC, AMC, Amsterdam, The Netherlands;2. Electrophysiology and Heart Modeling Institute, IHU Liryc, Fondation Bordeaux Université, Pessac-Bordeaux, France;3. Institut de Mathématiques de Bordeaux, UMR5251, Centre National De La Recherche Scientifique, Bordeaux, France;4. CARIM School for Cardiovascular Disease, Maastricht University Medical Centre, Maastricht, The Netherlands;6. Department of Medical Biology, Amsterdam UMC, AMC, Amsterdam, The Netherlands
Abstract:
Keywords:Long QT syndrome  Torsades de pointes arrhythmia  Repolarization  Reentry  Restitution
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