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Hematopoietic Tumors in a Mouse Model of X-linked Chronic Granulomatous Disease after Lentiviral Vector-Mediated Gene Therapy
Authors:Raisa Jofra Hernández  Andrea Calabria  Francesca Sanvito  Fabiola De Mattia  Giada Farinelli  Serena Scala  Ilaria Visigalli  Nicola Carriglio  Maura De Simone  Michela Vezzoli  Francesca Cecere  Maddalena Migliavacca  Luca Basso-Ricci  Maryam Omrani  Fabrizio Benedicenti  Rossana Norata  Paola Maria Vittoria Rancoita  Clelia Di Serio  Alessandra Mortellaro
Affiliation:1. San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy;2. GLP Test Facility, San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy;3. Pathology Unit, Department of Experimental Oncology, IRCCS San Raffaele Scientific Institute, Milan, Italy;4. Pediatric Immunohematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy;5. University Centre for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy;7. Medical School, Vita-Salute San Raffaele University, Milan, Italy;8. Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy
Abstract:
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  • Keywords:X-linked chronic granulomatosis disease  gene therapy  lentiviral vectors  myelodysplastic syndrome  inflammation  mouse model  Good Laboratory Practice  GLP
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