Cancer-related Fatigue in Breast Cancer Survivors: A Review |
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| Authors: | Ana Ruiz-Casado Alejandro Álvarez-Bustos Cristina G de Pedro Marta Méndez-Otero María Romero-Elías |
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| Institution: | 1. Department of Medical Oncology, University Hospital Puerta de Hierro-Majadahonda, Madrid, Spain;2. Biomedical Research Foundation, Getafe University Hospital, Madrid, Spain;3. Department of Sport Sciences, Sport Research Centre, Miguel Hernandez University of Elche, Alicante, Spain;1. Department of Surgery, Mercy Breast Clinic, Coletta, Oklahoma City, OK;2. Department of Breast Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL;3. Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL;1. Department of Medicine, Medical College of Wisconsin, Milwaukee, WI;2. Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI;3. Department of Pharmacy, Froedtert & the Medical College of Wisconsin, Milwaukee, WI;4. Center for Advancing Population Science, Medical College of Wisconsin, Milwaukee, WI;1. Academic Division of Gynecology and Obstetrics, Mauriziano Hospital, University of Turin, Turin, Italy;2. School of Medicine, University of Turin, Turin, Italy;1. Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ;2. Department of SurgeryRutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ;3. Department of MedicineRutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ;4. Department of Radiation Oncology, Wexner Medical Center, Ohio State University, Columbus, OH;1. Allina Health System, Virginia Piper Cancer Institute, Minneapolis, MN;2. Hospital Pathology Associates, Allina Health Laboratories, Minneapolis, MN;3. Research Informatics, Allina Health System, Minneapolis, MN;1. Department of Radiology, University of Wisconsin, Madison, WI;2. Department of Medical Physics, University of Wisconsin, Madison, WI;3. Carbone Cancer Center, University of Wisconsin, Madison, WI;4. Department of Medicine, University of Wisconsin, Madison, WI;5. Department of Human Oncology, University of Wisconsin, Madison, WI;6. Department of Surgery, University of Wisconsin, Madison, WI |
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| Abstract: | Fatigue has been the most distressing and frequent symptom in breast cancer (BC) survivors after treatment. Although fatigue can occur in other cancer survivors, women with a history of BC might share some distinctive features. The present study aimed to recapitulate the knowledge about risk factors and correlates of cancer-related fatigue (CRF) in BC survivors after oncologic therapy. An electronic data search was conducted in PubMed using the terms “fatigue,” “breast,” “cancer,” and “survivors.” Records were included if they were original articles, available in English, had used a quantitative scale, had > 100 participants, and had excluded women with BC relapse. BC survivors were required to have finished their treatments ≥ 2 months before, except for hormonal therapy. The physiopathology and other interventions were considered beyond the scope of our review. The correlates were subsequently classified into 7 main categories: (1) sociodemographic data, (2) physical variables, (3) tumor- and treatment-related variables, (4) comorbidities, (5) other symptoms, (6) psychological issues, and (7) lifestyle factors. Fatigue was consistently greater in younger, obese, and diabetic women. Women reporting fatigue often communicated symptoms such as pain, depression, insomnia, and cognitive dysfunction. Coping strategies such as catastrophizing could play an important role in the persistence of fatigue. However, tumor characteristics, previous treatments received, and physical activity were not consistently reported. CRF was a strong predictor of the quality of life of BC survivors after treatment. In conclusion, we found CRF was a frequent and serious symptom that severely affects the quality of life of BC survivors after treatment. Health practitioners require more awareness and information about CRF. |
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| Keywords: | BC Coping strategies CRF Quality of life Survivors |
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