Developing a databank for multiple transfusion patients: Rh antigen and phenotype distribution among 3000 regular blood donors in Iran |
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| Authors: | Zahra Bakhshandeh Naser Amirizadeh Mahtab Maghsoodlu Arezoo Oodi Amirali Naghi Ali Arab Khazaeli Azita Azarkeivan |
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| Affiliation: | 1. Department of Pediatrics, Hematology and Oncology, Medical University of Warsaw, Zwirki i Wigury str. 63A, 02- 091 Warsaw, Poland;2. Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Zwirki i Wigury str. 63A, 02- 091 Warsaw, Poland;3. Institute of Hematology and Transfusion Medicine, Warsaw, Poland Indiry Gandhi str. 14, 02-776 Warsaw, Poland;4. Stem Cell Bank, Central Clinical Hospital Warsaw Medical University, Poland, Zwirki i Wigury str. 63A, 02- 091 Warsaw, Poland;5. Department of Pediatrics Oncology, Children’s Memorial Health Institute, Warsaw, Poland, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland;1. Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA;2. Department of Pharmacy, Yale New Haven Health, New Haven, CT, USA;3. Department of Internal Medicine, Section of Hematology, Yale School of Medicine, New Haven, CT, USA;4. Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA;1. UT Southwestern Medical School, 5323 Harry Hines Blvd, Dallas, TX, 75390, United States;2. UT Rio Grande Valley School of Medicine, 1201 W University Dr, Edinburg, TX, 78539, United States;3. Division of Transfusion Medicine and Hemostasis, Department of Pathology, UT Southwestern Medical Center, Dallas, TX, 75390, United States;4. Division of Hematology/Oncology, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, 75390, United States;1. Department of Laboratory Medicine, Tama-Hokubu Medical Center, Tokyo Metropolitan Health and Medical Treatment Corporation, Tokyo, Japan;2. Department of Hematology, Tama-Hokubu Medical Center, Tokyo Metropolitan Health and Medical Treatment Corporation, Tokyo, Japan;3. Japanese Red Cross Kanto-Koshinetsu Block Blood Center, Tokyo, Japan;4. Clinical Research Support Center, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan;1. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada;2. Department of Anesthesiology, Pharmacology, and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada;3. Centre for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada;4. Department of Cardiothoracic Anesthesiology, Copenhagen University Hospital, Copenhagen, Denmark |
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| Abstract: | BackgroundRhesus (Rh) blood group system is clinically the most significant protein-based grouping system. The Rh system is of vital importance in blood transfusion, and incompatibility between the donor and recipient leads to alloimmunization. Alloimmunization is commonly seen in multiple-transfusion recipients (e.g. thalassemia patients). There are a few studies about the prevalence of Rh antigens, except for D, in Iran; and regarding the high prevalence of thalassemia in the country, in this study we have determined antigens and phenotypes of the Rh among population of regular blood donors with the aim of developing a detailed Rh databank.Materials and methodsThis cross-sectional study randomly enrolled 3000 regular blood donors from three provinces of Sistan-Balouchestan, Khuzestan and Gilan in Iran, from September 2018 to May 2019. A fully automated system, based on hemagglutination, was used to Rh typing of blood samples.ResultsThe prevalence of Rh antigens were as follows: D: 88.9 %; E: 30.9 %; C: 74.1 %; e: 96.2 %; and c: 72.8 %. The most common antigen and phenotype were "e" and R1r (DCcee), respectively.ConclusionDue to the high rate of alloimmunization incidence against Rh blood group antigens among multiple transfusion recipients, development of regular blood donor's Rh databank can facilitate extensive matching for the Rh antigens and it likely reduces the risk of alloimmunization. |
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| Keywords: | Rh-Hr blood-group system Blood transfusion Alloimmunization Databank |
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