Reduction of toxicity in brachytherapy using a new technique |
| |
Authors: | Yuji Miyazaki Yukiho Takenaka Yasutaka Noda Nobuyuki Kawai Takanori Yoshikawa Takahito Wakamiya Isao Hara Tetsuo Sonomura |
| |
Institution: | 1. Department of Central Radiology, Wakayama Medical University Hospital, Wakayama, Japan;2. Department of Radiology, Wakayama Medical University, Wakayama;3. Clinical Research Center, Wakayama Medical University, Wakayama;4. Department of Urology, Wakayama Medical University, Wakayama Prefecture, Japan |
| |
Abstract: | PurposeThe purpose of the study was to elucidate the usefulness of a dose evaluation method for reducing late genitourinary (GU) toxicity in high-dose-rate brachytherapy (HDR-BT) of prostate cancer.Methods and MaterialsGU toxicity was scored in accordance with the Common Terminology Criteria for Adverse Events version 4.0. The prostatic urethra was divided into three segments (base = B, midgland = M, apex = A), which were subclassified into seven subgroups (B, M, A, BM, BA, MA, BMA) using a D10% color map of the urethra. Significance testing was conducted on urethral D0.1% and D10% among the seven subgroups. Grade < 2 GU toxicity was also implemented.ResultsData of 174 patients with localized prostate cancer treated with HDR-BT combined with external beam radiotherapy between November 2011 and July 2014 were analyzed retrospectively. Median age was 74 (53–84) years, and median followup period was 44 (6–69) months. The number of Grade < 2 and Grade ≥ 2 toxicity was significantly different in the M subgroup than in the other subgroups (p < 0.05), suggesting increased radioresistance in the midgland urethra.ConclusionsA high-dose-area evaluation method using a urethral D10% color map may be helpful in reducing late GU toxicity in HDR-BT for prostate cancer. |
| |
Keywords: | Brachytherapy/AE Brachytherapy/MT Prostatic neoplasms/RT Urethra/RE Risk factors |
本文献已被 ScienceDirect 等数据库收录! |
|