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STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma
Authors:Biniam Adane  Gabriela Alexe  Bo Kyung A. Seong  Diana Lu  Elizabeth E. Hwang  Denes Hnisz  Caleb A. Lareau  Linda Ross  Shan Lin  Filemon S. Dela Cruz  Melissa Richardson  Abraham S. Weintraub  Sarah Wang  Amanda Balboni Iniguez  Neekesh V. Dharia  Amy Saur Conway  Amanda L. Robichaud  Benjamin Tanenbaum  Kimberly Stegmaier
Affiliation:1. Dana-Farber/Boston Children''s Cancer and Blood Disorders Center, Boston, MA, USA;2. Broad Institute of MIT and Harvard, Cambridge, MA, USA;3. Bioinformatics Graduate Program, Boston University, Boston, MA, USA;4. Whitehead Institute for Biomedical Research, Cambridge, MA, USA;5. Department of Pathology, Stanford University, Stanford, CA, USA;6. Department of Pathology, Massachusetts General Hospital, Charlestown, MA, USA;7. Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA;8. Department of Pathology, Dalhousie University, Halifax, NS, Canada;9. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA;10. Department of Pediatrics and Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada;11. Children''s Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada
Abstract:
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  • Keywords:cohesin  Ewing sarcoma  fusion oncoprotein  metastasis  STAG2  STAG1  EWS/FLI1  PRC2  POU3F2
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