Influence of the BDNF Val66Met polymorphism on weight loss after bariatric surgery: a 24-month follow-up |
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| Authors: | Elionora Peña Assumpta Caixàs Concepción Arenas Rocio Pareja Josep León-Mengíbar Mercedes Rigla Timothy R Powell Narcís Cardoner Araceli Rosa |
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| Institution: | 1. Secció de Zoologia i Antropologia Biològica, Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain;2. Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain;3. Endocrinology and Nutrition Department, Hospital Universitari Parc Tauli, Sabadell, Spain;4. Medicine Department Universitat Autònoma de Barcelona, Sabadell, Spain;5. Institut d’Investigació i Innovació Parc Taulí, Sabadell, Spain;6. Secció d’Estadística, Departament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain;7. Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom;8. Division of Infectious Diseases, Weill Cornell Medicine, Cornell University, New York, New York;9. Mental Health Department, Hospital Universitari Parc Taulí, Sabadell, Spain;10. Depression and Anxiety Program, Department of Mental Health, Hospital Universitari Parc Taulí, Sabadell, Spain;11. Department of Psychiatry and Legal Medicine, Universitat Autònoma de Barcelona, Sabadell, Spain;12. Centre for Biomedical Research Network on Mental Health, Instituto de Salud Carlos III, Barcelona, Spain |
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| Abstract: | BackgroundBariatric surgery is currently the most effective long-term treatment for severe obesity. However, interindividual variation in surgery outcome has been observed, and research suggests a moderating effect of several factors including baseline co-morbidities (e.g., type 2 diabetes T2D] and genetic factors). No data are currently available on the interaction between T2D and variants in brain derived neurotrophic factor (BDNF) and its effect on weight loss after surgery.ObjectivesTo examine the role of the BDNF Val66Met polymorphism (rs6265) and the influence of T2D and their interaction on weight loss after bariatric surgery in a cohort of patients with severe obesity.SettingUniversity hospital in Spain.MethodsThe present study evaluated a cohort of 158 patients with obesity submitted to bariatric surgery (Roux-en-Y gastric bypass or sleeve gastrectomy) followed up for 24 months (loss to follow-up: 0%). During the postoperative period, percentage of excess body mass index loss (%EBMIL), percentage of excess weight loss (%EWL), and total weight loss (%TWL) were evaluated.ResultsLongitudinal analyses showed a suggestive effect of BDNF genotype on the %EWL (P = .056) and indicated that individuals carrying the methionine (Met) allele may experience a better outcome after bariatric surgery than those with the valine/valine (Val/Val) genotype. We found a negative effect of a T2D diagnosis at baseline on %EBMIL (P = .004). Additionally, we found an interaction between BDNF genotype and T2D on %EWL and %EBMIL (P = .027 and P = .0004, respectively), whereby individuals with the Met allele without T2D displayed a greater %EWL and greater %EBMIL at 12 months and 24 months than their counterparts with T2D or patients with the Val/Val genotype with or without T2D.ConclusionOur data showed an association between the Met variant and greater weight loss after bariatric surgery in patients without T2D. The presence of T2D seems to counteract this positive effect. |
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| Keywords: | Obesity Bariatric surgery Weight loss BMI Follow-up Type 2 diabetes rs6265 |
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