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Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade
Authors:Shivani Srivastava  Scott N. Furlan  Carla A. Jaeger-Ruckstuhl  Megha Sarvothama  Carolina Berger  Kimberly S. Smythe  Sarah M. Garrison  Jennifer M. Specht  Sylvia M. Lee  Robert A. Amezquita  Valentin Voillet  Vishaka Muhunthan  Sushma Yechan-Gunja  Smitha P.S. Pillai  Christoph Rader  A. McGarry Houghton  Robert H. Pierce  Raphael Gottardo  Stanley R. Riddell
Affiliation:1. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;2. Department of Pediatrics, University of Washington, Seattle, WA, USA;3. Department of Medicine, University of Washington, Seattle, WA, USA;4. Vaccine and Infections Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;5. Department of Comparative Medicine, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;6. Department of Immunology and Microbiology, Scripps Research Institute, Jupiter, FL, USA
Abstract:
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  • Keywords:CAR-T cells  ROR1  KP  lung adenocarcinoma  oxaliplatin  immunogenic cell death  alveolar macrophage  CXCR6  CXCR3
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