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Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress
Authors:Anish Thomas  Nobuyuki Takahashi  Vinodh N. Rajapakse  Xiaohu Zhang  Yilun Sun  Michele Ceribelli  Kelli M. Wilson  Yang Zhang  Erin Beck  Linda Sciuto  Samantha Nichols  Brian Elenbaas  Janusz Puc  Heike Dahmen  Astrid Zimmermann  Jillian Varonin  Christopher W. Schultz  Sehyun Kim  Craig J. Thomas
Affiliation:1. Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA;2. Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institute of Health, Rockville, MD 20850, USA;3. EMD Serono Research and Development Institute Inc., Biopharma R&D, Translational Innovation Platform Oncology, Billerica, MA 01821, USA;4. Merck KGaA, Biopharma R&D, Translational Innovation Platform Oncology, Frankfurter Street 250, 64293 Darmstadt, Germany;5. Technology Transfer Center, National Cancer Institute, 9609 Medical Center Dr, Rockville, MD 20850, USA;6. Clinical Pharmacology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA;7. Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA;8. Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA;9. Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA;10. A business of Merck KGaA, Darmstadt, Germany
Abstract:
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  • Keywords:replication stress  DNA damage response  cell-cycle checkpoints  SCLC  small cell neuroendocrine cancers  translational research  DNA topoisomerases  ataxia telangiectasia mutated and rad3 related
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