| 血脂调节剂的研究——Ⅰ.HMG-CoA还原酶抑制剂M-8614A及MH-2688B产生菌的筛选 |
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| 引用本文： | 何璧梅,姚国柱,张辉,徐寅正,隆泉.血脂调节剂的研究——Ⅰ.HMG-CoA还原酶抑制剂M-8614A及MH-2688B产生菌的筛选[J].中国抗生素杂志,1993(2). |
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| 作者姓名： | 何璧梅 姚国柱 张辉 徐寅正 隆泉 |
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| 作者单位： | 四川抗菌素工业研究所 成都610051
(何璧梅，姚国柱，张辉，徐寅正)，四川抗菌素工业研究所 成都610051(隆泉) |
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| 摘 要： | 利用酶联免疫吸附测定法,酶标β-羟基β-甲基-戊二酸单酰铺酶A(HMG-CoA)还原酶抑制剂Compactin抗体,定向筛选血脂调节剂。从青霉M-8614菌株发酵液中分离到M-8614A。该物质理化性质及波谱解释表明与Mevastatin为同一物质。 M-8614菌株用亚硝酸盐等诱变剂处理,从诱变株MH-2688发酵液中分离到MH-2688B。该物质理化性质及波谱解释表明与Lovastatin为同一物质。
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| 关 键 词： | HMG-CoA还原酶抑制剂 酶联免疫吸附测定法 Mevastatin Lovastatin 鉴别 |
STUDY ON LIPEMIA MODULATOR ?. SCREENING OF PRODUCING STRAN OF HMG-CoA REDUCTASE INHIBITOR M-86 14A AND MH-2688B |
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| He Bi-mei,Yao Guo-zhu,Zhang Hui,Xu Yin-zheng and Long Qung.STUDY ON LIPEMIA MODULATOR ?. SCREENING OF PRODUCING STRAN OF HMG-CoA REDUCTASE INHIBITOR M-86 14A AND MH-2688B[J].Chinese Journal of Antibiotics,1993(2). |
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| Authors: | He Bi-mei Yao Guo-zhu Zhang Hui Xu Yin-zheng and Long Qung |
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| Abstract: | In the course of directed screening Lipemia modulator by enzyme labelled HMG-CoA reductase inhibitor Compactin antibody ELISA method. From the fermentation broth of Penicillium strain No. M-8614, a secondary metabolite designated as M-8614A compound was isolated.
Strain MH-2688 was selected,when M-8614 strain was further treated with nitrite, compound MH-2688B was isolated. Their structures were determined by physico-chemical properties and spectroscopic analysis. M-8614A is identical with Mevastatin (Compactin). MH-2688B is identical with Lovastatin (Monacolin K). |
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| Keywords: | HMG-CoA reductase inhibitor ELISA Mevastatin Lovastatin Identification |
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