Plk1与MUC4在胰腺癌中的表达与临床意义

目的：探讨胰腺癌中Plk1、MUC4表达的意义.方法：应用免疫组化EnVision两步法检测33例胰腺癌及其癌旁组织、3例胰腺浆液性囊腺瘤,3例黏液性囊腺瘤,5例慢性胰腺炎中Plk1、MUC4的表达.结果：胰腺癌中Plk1、MUC4的阳性表达率分别为72.7%（24/33）、51.5%（17/33）,与胰腺癌患者的年龄、性别、临床分期、组织学分级、淋巴结的浸润、肿瘤的部位无显著相关（P＞0.05）.癌旁组织、慢性胰腺炎和良性胰腺肿瘤组织中Plk1、MUC4表达均为阴性.结论：Plk1、MUC4在胰腺癌中表达具有一定肿瘤特异性,可能是胰腺癌治疗的两个理想靶目标.

Expression of Plk1 and MUC4 gene in pancreatic carcinoma and their clinical significance

Objective: To determine the expression status of Plk1 and MUC4 genes in pancreatic carcinoma. Methods: Expression of Plk1 and MUC4 genes was evaluated by immunohistochemistry in 33 cases of pancreatic carcinoma along with their corresponding adjacent benign tissues, 3 cases of pancreatic serous cystadenoma, 3 cases of pancreatic mucinous cystadenoma and 5 cases of chronic pancreatitis. Results:The positive expression rate of Plk1 and MUC4 genes in pancreatic carcinoma was 72.7%(24/33) and 51.5%(17/33), respectively. There was no relationship between the expression of Plk1 and MUC4 genes and patients'age, sex, clinical staging, histologic grading, nodes invasion and the location of the tumor (P > 0.05). No expression of Plk1 and MUC4 genes was detected in benign tissue adjacent to the tumors, chronic pancreatitis and benign pancreatic tumors. Conclusion:The expression of Plk1 and MUC4 genes appears to be tumor specific to some extent in our pancreatic carcinoma samples. Plk1 and MUC4 may be two ideal targets for therapy against pancreatic carcinoma.