| 剑麻皂素的硫酸酯化的研究 |
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| 引用本文： | 韩耀玲,张东娣,林翠梧. 剑麻皂素的硫酸酯化的研究[J]. 河南大学学报(医学版), 2007, 26(4): 31-33 |
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| 作者姓名： | 韩耀玲 张东娣 林翠梧 |
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| 作者单位： | 河南大学,药学院,河南,开封,475001;广西大学,化学化工学院,广西,南宁,53004 |
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| 摘 要： | 目的:将分离出的剑麻皂素进行硫酸酯化,以期合成得到具有抗癌活性的剑麻皂素衍生物。方法:采用氯磺酸-吡啶法合成剑麻皂素硫酸酯。结果:工艺条件:反应温度为35℃,反应时间为24 h,原料(质量g)与吡啶(体积m l)的配比为1∶20,原料(质量g)与氯磺酸(体积m l)的配比为1∶5。同时对产品进行熔点、R f值、红外光谱、质谱表征,并作了生理活性的测定。结论:表明具有较高的抗肝癌活性。
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| 关 键 词： | 剑麻皂素 氯磺酸 硫酸酯化 |
| 文章编号： | 1672-7606(2007)04-0031-03 |
| 修稿时间： | 2007-07-28 |
Study on sulfolipid sulfate of tigogenin and its anticancer effect |
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| HAN Yao-ling,ZHANG Dong-di,LIN Cui-wu. Study on sulfolipid sulfate of tigogenin and its anticancer effect[J]. Journal of Henan University, 2007, 26(4): 31-33 |
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| Authors: | HAN Yao-ling ZHANG Dong-di LIN Cui-wu |
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| Abstract: | Objective: To make tigogenin derivate tigogenin sulfate that shows high biological activity of liver anticancer.Methods: Tigogenin was sulfated with chlorsulfonic acid.Results: Technologic conditions were determined.Reactive temperature was 35 ℃,reactive time was 24 h,the mass(g) of the material and the volume(ml) of pyridinium were 1∶20,the mass(g) of the material,and the volume(ml) of chlorosulfonic acid was 1∶5.At the same time,the natures of tigogenin sulfate including melting point Rf value,IR,MS were analyzed,besides,biological activity was determined.Conclusion: The result showed that sulfolipid sulfate of tigogenin has high biological activityon liver anticancer |
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| Keywords: | Tigogenin Chlorosulfonic acid Sulfation |
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