| 慢性心力衰竭患者血红蛋白(Hb)、血清肿瘤坏死因子和AngⅡ水平变化及其干预研究 |
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| 引用本文： | 黄郁玲,郗爱旗,褚以德,赵文蕊,尚玲,钟欣,李英兰,廖宝霞,李国峰.慢性心力衰竭患者血红蛋白(Hb)、血清肿瘤坏死因子和AngⅡ水平变化及其干预研究[J].青海医药杂志,2008,38(2):1-5. |
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| 作者姓名： | 黄郁玲 郗爱旗 褚以德 赵文蕊 尚玲 钟欣 李英兰 廖宝霞 李国峰 |
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| 作者单位： | 青海省人民医院老年医学研究所,810007 |
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| 基金项目： | 青海省科技厅自然科学基金 |
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| 摘 要： | 目的:研究慢性心力衰竭(CHF)患者血红蛋白(Hb)、血清肿瘤坏死因子(TNF-α)和(AngⅡ)水平的变化及其干预治疗。方法:对入选的319例CHF患者分为A组和B组,并按Hb水平分为贫血组和非贫血组,于治疗前后测定了Hb、血清TNF-α和AngⅡ水平,超声心动图测量左室射血分数(LVEF),评价心功能。结果:随着心功能恶化,Hb水平逐渐降低,而血清TNF-α和AngⅡ水平逐渐升高;CHF贫血组患者血清TNF-α和AngⅡ水平明显高于非贫血组患者(P<0.01);CHF患者Hb水平与TNF-α和AngⅡ水平呈负相关(P<0.01)。采用不同方案治疗后的结果显示,联合用药治疗CHF患者优于单一药物;CHF贫血患者在贫血纠正后,血清TNF-α和AngⅡ水平恢复到非贫血组患者水平。结论:TNF-α和AngⅡ在CHF贫血发生发展的病理生理过程中起着重要作用;积极纠正贫血,规范的治疗可显著降低血清TNF-α和AngⅡ水平,从而改善CHF患者心脏功能和预后。
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| 关 键 词： | 心力衰竭 血红蛋白 肿瘤坏死因子-α 血管紧张素Ⅱ 干预 |
The Change of Hemoglobin(Hb) Concentration, Tumor Necrosis Factor-α,Angiotensin Ⅱand Its Intervention Study in Patients with Congestive Heart Failure |
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| Xi Aiqi,Chu Yide,Zhao Wenrui,Huang Yuling,Shang Ling,Zhong Xin,Li Yinglan,Liao Baoxia,Li Guofeng.The Change of Hemoglobin(Hb) Concentration, Tumor Necrosis Factor-α,Angiotensin Ⅱand Its Intervention Study in Patients with Congestive Heart Failure[J].Qinghai Medical Journal,2008,38(2):1-5. |
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| Authors: | Xi Aiqi Chu Yide Zhao Wenrui Huang Yuling Shang Ling Zhong Xin Li Yinglan Liao Baoxia Li Guofeng |
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| Institution: | Xi Aiqi; Chu Yide; Zhao Wenrui; Huang Yuling; Shang Ling; Zhong Xin; Li Yinglan; Liao Baoxia; Li Guofeng The People s Hospital of Qinghai Province; Xining (810007); |
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| Abstract: | Objective:To study the changes of hemoglobin (Hb) concentration, tumor necrosis factor-α (TNF-α), AngiotensinⅡ (AngⅡ), and the effect of intervention on Hb concentration and parameters in patients with congestive heart failure (CHF). Methods: 319 patients with CHF were divided into two group: the A group and B group. Blood samples were drawn from mediam cubital veins of the patient at the beginning of the study and follow-up after the 6-month.Hb concentration, serum level of TNF-α and AngⅡ were measured. Le... |
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| Keywords: | Congestive heart failure （CHF） Hemoglobin concentration Anemia TNF-α Angiotensin Ⅱ |
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