| 槲皮素对INH诱导的大鼠肝损伤及肝组织Bcl-2和Bax表达的影响 |
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| 引用本文： | 卢春凤,陈廷玉,赵锦程,王淑秋,张建华,李怀荆,李永毅. 槲皮素对INH诱导的大鼠肝损伤及肝组织Bcl-2和Bax表达的影响[J]. 解剖学研究, 2010, 32(1): 28-31 |
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| 作者姓名： | 卢春凤 陈廷玉 赵锦程 王淑秋 张建华 李怀荆 李永毅 |
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| 作者单位： | 佳木斯大学基础医学院,黑龙江,佳木斯,154007 |
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| 基金项目： | 黑龙江省卫生厅项目(2009-348);;佳木斯大学人才培养基金项目(RC2009-029) |
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| 摘 要： | 目的探讨槲皮素对异烟肼(INH)致大鼠肝损伤的保护作用。方法将动物随机分为正常对照组、INH组、槲皮素低剂量组、槲皮素高剂量组,灌胃染毒,每天1次,14d后测定大鼠血清中天冬氨酸氨基转移酶(AST)和丙氨酸氨基转移酶(ALT)的活性,肝匀浆中丙二醛(MDA)含量、谷胱甘肽过氧化物酶(GSH-Px)和超氧化物歧化酶(SOD)活性,用Westernblot法检测肝组织中Bcl-2和Bax蛋白的表达。结果与正常对照组比较,INH组大鼠血清AST和ALT的活性增强,肝组织的MDA含量升高,SOD和GSH-Px活性降低,Bcl-2蛋白表达减少,而Bax蛋白表达增加;高剂量槲皮素可减轻INH所致的损伤。结论槲皮素对INH所致的大鼠肝损伤具有保护作用,可能与其抗脂质过氧化作用及调节凋亡相关蛋白Bcl-2和Bax的表达有关。
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| 关 键 词： | 槲皮素 异烟肼 肝 Bcl-2 Bax |
Effect of Quercetin on INH injuried liver and expressions of Bcl-2 and Bax in liver |
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| LU Chun-feng,CHEN Ting-yu,ZHAO Jin-cheng,WANG Shu-qiu,ZHANG Jian-hua,LI Huai-jing,LI Yong-yi. Effect of Quercetin on INH injuried liver and expressions of Bcl-2 and Bax in liver[J]. Anatomy Research, 2010, 32(1): 28-31 |
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| Authors: | LU Chun-feng CHEN Ting-yu ZHAO Jin-cheng WANG Shu-qiu ZHANG Jian-hua LI Huai-jing LI Yong-yi |
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| Affiliation: | LU Chun-feng,CHEN Ting-yu,ZHAO Jin-cheng,WANG Shu-qiu,ZHANG Jian-hua,LI Huai-jing,LI Yong-yi.Basic Medical College,Jiamusi University,Jiamusi 154007 China |
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| Abstract: | Objective To investigate the protective effects of Quercetin on liver injury induced by Isoniazid(INH) in rats.Methods The animals were assigned randomly into four groups,including normal control group,INH group,Quercetin low dosage group,Quercetin high dosage group.Rats were administered intragastrically once a day.After 14 days,measurements were made in both serum and homogenized liver tissues.The activities of serum AST and ALT,the level of malondialdehyde(MDA),the activities of glutathione peroxidase(GS... |
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| Keywords: | Quercetin Isoniazid Liver Bcl-2 Bax |
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