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| 肺癌、癌旁和正常组织中33种元素的分布特征 | |
| 引用本文： | 张霖琳,马千里,吴国平,黄云超,魏复盛. 肺癌、癌旁和正常组织中33种元素的分布特征[J]. 卫生研究, 2010, 39(3) |
| 作者姓名： | 张霖琳 马千里 吴国平 黄云超 魏复盛 |
| 作者单位： | 1. 北京科技大学土木与环境工程学院,北京,100083 2. 中国环境监测总站 3. 昆明医学院第三附属医院 |
| 基金项目： | 中美科技合作课题国家环境保护部资助项目(No.2005-2-01) |
| 摘 要： | 目的分析肺癌患者肺癌、癌旁和正常组织中33种元素的浓度水平及其分布规律。方法在中国肺癌高发区收集14例确诊肺癌患者的肺组织样品,用微波消解法对样品进行前处理,电感耦合等离子体质谱法测定肺组织中33种元素的浓度,用SAS9.0软件对实验结果进行统计分析。结果B、V、Fe、Ni、Cu、Zn、Ga、Se、Rb、Cd、Pb和Bi12种元素在肺癌和正常组织中存在显著性差异(P0.05),将元素浓度作为自变量逐步引入条件Logistic回归模型,Fe、Ni、Cu、Zn和Pb5种元素进入方程,提示Fe和Zn是肺癌发生的保护元素,Ni、Cu和Pb是危险元素,对这5种元素进行Pearson相关性检验,Fe和Zn、Ni和Cu、Cu和Pb呈显著正相关,Fe和Ni、Fe和Cu、Ni和Zn、Cu和Zn呈显著负相关(P0.05),Cu/Zn比值在肺癌组织显著升高。结论肺癌、癌旁和正常组织中某些元素浓度的分布与肺癌的发生有一定的关联性。 |
| 关 键 词： | 肺癌 组织 元素 |
Distribution of 33 elements in lung cancer tissues,paracancerous lung tissues and benign lung tissues of patients with lung cancer |
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| ZHANG Linlin,MA Qianli,WU Guoping,HUANG Yunchao,WEI Fusheng. Distribution of 33 elements in lung cancer tissues,paracancerous lung tissues and benign lung tissues of patients with lung cancer[J]. Journal of hygiene research, 2010, 39(3) | |
| Authors: | ZHANG Linlin MA Qianli WU Guoping HUANG Yunchao WEI Fusheng |
| Affiliation: | ZHANG Linlin,MA Qianli,WU Guoping,HUANG Yunchao,WEI Fusheng The Civil , Environment Engineering School of University of Science , Technology Beijing,Beijing 100083,China |
| Abstract: | Objective To analyze the contents and distribution of 33 elements in the samples of lung cancer tissues,paracancerous lung tissues and benign lung tissues of patients with lung cancer.Methods 14 samples of lung cancer tissue,paracancerous lung tissue and benign lung tissue were collected from the patients with lung cancer in the high lung cancer rate area of our country.The samples were determined by inductively coupled plasma mass spectrometry after microwave digestion.SAS 9.0 software was used to analyze ... |
| Keywords: | lung cancer tissue elements |
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