子宫颈小细胞癌临床病理分析

目的:探讨原发性宫颈小细胞癌(SCCC)的临床病理特征、免疫组化特点及鉴别诊断。方法对1例宫颈小细胞癌进行组织病理学观察、免疫组化检测和文献复习。结果:组织学显示为3种不同分化的细胞区域,小细胞区肿瘤细胞小而圆,胞质少,核染色质深,核仁不明显,分裂相活跃,可见坏死,肿瘤细胞呈片状浸润;合并鳞癌及腺癌分化。免疫组化:小细胞癌CK、NSE和Syn(+),CgA和LCA(-);腺癌CEA(+)。结论:宫颈小细胞癌是一种少见的高度恶性肿瘤,具有特征性的形态学改变,应与宫颈的小细胞鳞状细胞癌、淋巴瘤、肺转移性小细胞癌、胚胎性横纹肌肉瘤、宫内膜间质肉瘤等进行鉴别。

Small cell carcinoma of cervix:a clinicopathologic analysis

Objective:To explore the histopathologic and immunohistochemical characteristics of small cell carcinoma of the cervix (SCCC) and its differential diagnosis. Methods:One cases of primary small cell carcinoma in the cervix were studied by morphologic and immunohistochemical techniques and the related literature was reviewed. Results:Histologically it contained three different areas of cell differentiation. The neoplastic cells appeared small,round in solid sheets,scant cytoplasm,hyperchromatic neclei and absence of nucleoli. Numerous mitotic figures and extensive necrosis were also common findings. The foci of squanmous cell carcinoma or adenocarcinoma were identified. Immunohistochemically ,the small cells were positive for NSE、Syn、CK. Conclusion:SCCC is a rare and highly malingnant tumor with distinct pathological features. Differential diagnosis of it includes small cell squamous carcinoma ,lymphoma ,metastatic small cell carcinoma from the lung ,embryonal rhabdomyosarcoma ,endometrial stroma sarcoma etc.