32例精神分裂症患者氯丙嗪治疗前后的血液流变学观察

研究目的探讨精神分裂症病人血液流变学异常的原因及氯丙嗪治疗精神分裂症的机理是否与改善血流的流变性有关。研究方法入组的32例病人于治疗前作第1次抽血及简明精神病量表（BPRS）评定。采用上海医科大学研制的XN3－电子自动全血粘度红细胞电泳仪，测定血液流变学指标。经氯丙嗪治疗2周后，重复上述实验及第2次BPRS评定。统计学处理采用t检验。结果32例精神分裂症病人治疗前血液流变学指标较正常人有明显异常，经氯丙嗪治疗后，全血高切变、全血低切变、红血球压积和红血球电泳时间有显著下降，同时BPRS评分也下降，其差异均有显著意义（P＜0．05）。结论精神分裂症病人接受氯丙嗪治疗2周后，血液流变学指标有不同程度改善，患者临床症状同时缓解。

The observations of blood rheology in 32 schizophreniacs during pre-treatment and Post-treatment

To research both the cause of abnormality of blood rheological indices and relationship between the mechanism of chlorpromazine treatment and improvement of the rheological indices in patients with schizophreniacs.Methods Before treatment, the first hemospasia and BPRS evaluation were taken, and indices of blood rheology measured using XNs Electron Auto Whole Blood Viscosity Red Cell Electrophoresis Apparatus (researched and produced by Shanghai Medical University) in the 32 schizophrenics. After 2-week chlorpromazine treatment, the above-mentioned trials were replicated and the second BPRS evaluation made. The t-test were used for statistical treatthent. Results Compared to normals, there were significant abnormality of blood rheological indices in 32 schizophrenics before treatment. After chlorpromazine treatment, there were obvious decrease in whole blood specific viscosity under both the high and low pressures, hematocrit, red cell electrophoresis duration. The BPRS scores also decreased. All the differences were significant (P < 0.05).Concintion The blood rheology are abnormal in schizophrenia. After 2-week chlorpromazine treatment, there are improvement of the indices of blood rheology in different degree. Clinical symptoms were simultaneously relieved in the patients.