Z-3-(2-羟基丁烯基)苯酞的合成研究

研究目的探讨苯酞类天然产物的合成方法及其生物活性。研究方法以邻苯二甲酐为底物，首先引入丁烯基，再进行烯丙位氧化，制得目标化合物。结果通过丁基锂反应，得到了具有药物活性的丁烯基苯酞，然后利用SeO2烯丙位氧化，首次合成了Z－3－（2－羟基丁烯基）苯酞。结论此合成方法原料易得，方法简便，为苯酞类化合物的合成研究提供了一个新的途径。

Synthessis of Z-2-3-(2-hydroxybutylidene)phthalide

To search the synthetic methods and biological activities of natural phthalides products.Methods To achieve our target compund through introducing of butenyl and than allylic oxidation from phthlic anhydride.Results Butylidenephthalide with biological activivies was synthesized by a reaction of phthalic anhydride witch then was oxided at allylic nethene using SeO2 to give first the Z-3 (2 - hydroxybutylidene) phthalide. Couclutiou Here we provide a new and convenient synthesis of Z-3-(2 hydroxybutylidene)phthalide. It is helpful to synthetic research on phthaliee.