| Ku80蛋白在乳腺癌组织中的表达及其临床意义 |
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| 引用本文： | 庄亮,于世英,熊慧华,黄晓园,许三鹏. Ku80蛋白在乳腺癌组织中的表达及其临床意义[J]. 中国肿瘤临床, 2004, 31(10): 587-589 |
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| 作者姓名： | 庄亮 于世英 熊慧华 黄晓园 许三鹏 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院肿瘤中心,武汉市,430030 |
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| 摘 要： | 目的:研究Ku80蛋白在乳腺癌的表达及与临床病理特征的关系.方法:采用免疫组化法检测65例乳腺癌组织Ku80、ER、PR、HER-2和突变型p53表达水平.结果:65例乳腺癌标本中Ku80、ER、PR、HER-2、p53阳性率分别为78.5%、40.0%、53.8%、44.6%和32.3%.Ku80表达水平与肿瘤大小、ER、PR、HER-2和p53的表达水平有关(P＜0.05),其中Ku80与HER-2密切相关(rs=0.319,P=0.010).结论:Ku80表达水平与影响乳腺癌患者预后的生物学特征相关,特别是与HER-2关系密切;Ku80与HER-2之间可能存在调控通路.
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| 关 键 词： | Ku80 HER-2 乳腺癌 预后 免疫组织化学 |
| 文章编号： | 1000-8179(2004)10-0587-04 |
The Expression and Significance of Ku80 in the Tissue of Breast Carcinoma |
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| Zhuang Liang Yu Shiying Xiong Huihua et alCancer Center,Tongji Hospital of Tongji Medical College,Wuhan. The Expression and Significance of Ku80 in the Tissue of Breast Carcinoma[J]. Chinese Journal of Clinical Oncology, 2004, 31(10): 587-589 |
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| Authors: | Zhuang Liang Yu Shiying Xiong Huihua et alCancer Center Tongji Hospital of Tongji Medical College Wuhan |
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| Abstract: | Objective: To study the expression of Ku80 in breastal carcinoma and to explore the correlation between the expression of Ku80 and the characters of clinic, pathology and biology. Methods: Immunohistochemistry was used to measure the expression of Ku80, ER, PR, HER-2 and mutant p53 in 65 cases of breast carcinoma. Results: The expression of Ku80 was 78.5% and was associated with the tumor size and the expressions of ER, PR, HER-2 and mutant p53 (P<0.05). It was positively correlated with HER-2(rs=0.319, P=0.010). Conclusions: The expression of Ku80 in breast carcinoma had close relationship with prognosis factors, especially with HER-2; there may be a modulation pathway between Ku80 and HER-2. |
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| Keywords: | Ku80 HER-2 Breast carcinoma Prognosis Immunohistochemistry |
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