冠心病患者行经皮冠状动脉内支架植入术前后C-反应蛋白的变化

为观察炎症因子C 反应蛋白在经皮冠状动脉内支架植入术前后的变化 ,探讨C 反应蛋白在急性冠状动脉综合征的意义 ,我们回顾性分析了 10 5例行冠状动脉内支架植入术患者及同期 2 4 2例行冠状动脉造影患者的资料 ;利用散射比浊法测量其术前术后C 反应蛋白。结果发现 ,行经皮冠状动脉内支架植入术的患者术后C 反应蛋白明显高于术前 (6 .7± 0 .5比 17.6± 1.0 ,P <0 .0 1) ,而冠状动脉造影组术前术后C 反应蛋白则无明显变化 (3.5±0 .7比 3.6± 0 .8,P >0 .0 5 )。因此 ,C 反应蛋白作为炎症的反应蛋白 ,在经皮冠状动脉内支架植入术后明显升高 ,可能与冠状动脉内支架术治疗后斑块撕裂、内皮损伤以及局部血管炎症有关 ,推测C 反应蛋白升高是急性冠状动脉综合征的一个表现。

Changes of Serum C-reactive Protein before and after Implantation of Intracoronary Stents in Patients with Coronary Heart Disease

Aim To examine the effect of implantation of intracoronary stents on the serum levels of C-creative protein (CRP). Methods This study included 105 patients who underwent implantation of intracoronary stents and 242 patients who received coronary angiography (CAG). Serum CRP was measured in the early morning before the procedure and the following morning after the procedure. Results In patients with implantation of stents, CRP levels after the procedure were significantly higher than that before procedure (6.7±0.5 vs 17.6±1.0, p<0.01). In CAG group, however, CRP levels after angiography were not significantly higher than that before angiography (3.5±0.7 vs 3.6±0.8, p>0.05). Conclusions Implantation of intracoronary stents leads to a detectable increase in serum levels of CRP, which is probably related with plaque rupture, the intrinsic inflammatory or tissue damage within arterial intima treated with stents implantation. It is suspected that increased-CRP may be a manifestation of acute coronary syndrome.