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| 青年和绝经后女性乳腺癌c-erbB-2、p53、ER和PR受体表达及意义 | |
| 引用本文： | 张英,刘永源,黄应桂,郑朝晖,梁启廉.青年和绝经后女性乳腺癌c-erbB-2、p53、ER和PR受体表达及意义[J].肿瘤防治研究,2004,31(2):79-80. |
| 作者姓名： | 张英 刘永源 黄应桂 郑朝晖 梁启廉 |
| 作者单位： | 1. 524001,广东湛江,广东医学院附属医院肿瘤内科 2. 524001,广东湛江,广东医学院附属医院普外科 3. 524001,广东湛江,广东医学院附属医院病理科 |
| 摘 要： | 目的 探讨青年和绝经后女性乳癌c erbB 2、p53、ER、PR的表达及意义。方法 采用SP法检测青年组 (13 1例 )与绝经组 (13 6例 )乳癌组织中各指标的表达及其与临床分期、腋淋巴结 (ALN )转移、3年无病生存率 (DFS)之间的关系。结果 c erbB 2阳性与临床分期、ALN转移相关 (P <0 .0 5) ,c erbB 2阳性者 3年DFS低于阴性者 (P <0 .0 5)。青年组c erbB 2、p53阳性率高、ER阳性率低 (P <0 .0 1) ,3年DFS低于绝经组 (P <0 .0 5)。结论 c erbB 2表达是乳腺癌预后重要指标 ,青年乳腺癌c erbB 2、p53阳性率高 ,ER阳性率低 ,3年DFS低 ,预后较差 |
| 关 键 词： | 乳腺肿瘤 c-erbB-2 p53 ER PR |
| 文章编号： | 1000-8578(2004)02-0079-02 |
| 收稿时间： | 2003-10-14 |
| 修稿时间： | 2003-11-14 |
Expression of c-erbB-2、p53、ER and PR between the Young and Postmenopausal Women With Breast Cancer |
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| ZHANG Ying,LIU Yong yuan,HUANG Ying gui,et al.Expression of c-erbB-2、p53、ER and PR between the Young and Postmenopausal Women With Breast Cancer[J].Cancer Research on Prevention and Treatment,2004,31(2):79-80. | |
| Authors: | ZHANG Ying LIU Yong yuan HUANG Ying gui |
| Institution: | ZHANG Ying,LIU Yong yuan,HUANG Ying gui,et al Department of Medical Oncology,Affiliated Hospital of Guangdong Medical College,Zhanjing 524001,China |
| Abstract: | Objective To study the expression of c erbB 2?p53?ER and PR between young and postmenopausal women with breast cancer. Methods The expression of c erbB 2?p53?ER and PR in 131 young women and 136 Postmenopausal women with breast cancer were studied by S? P immunohistochemistry,with its relation with clinical TNM stage?axillary lymph node(ALN) metastasis and 3 year disease-free survival(DFS). Results The expression of c erbB 2 correlated with clinical TNM stages and ALN metastasis( P < 0.05 ... |
| Keywords: | c-erbB-2 p53 ER PR |
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