黄连素与钙剂伍用治疗病态窦房结综合征初步观察

目的探讨黄连素与钙剂伍用对病态窦房结综合征的治疗作用。方法对符合病态窦房结综合征患者21例，口服黄连素片0．5～0.8g，每天3次，1周后同时加用10％葡萄糖酸钙10ml加5％葡萄糖或0．9％氯化钠液稀释静脉滴注8～10d。治疗前后分别作动态心电图检查，观察窦性最长R-R间期、窦性最短R-R间期、24h平均心率、24h总心搏数、长R-R间期(≥2s)、长R-R间期发生次数。结果治疗后最长窦性R-R间期、最短窦性R-R间期分别由(1．86±0．42)s、(0．76±0．15)s缩短至(1.67±0．63)s(P<0．05)、(0．66±0．10)s(P<0．01)。24h平均心率、24h总心搏数分别由(53．20±5．63)次／min、(73974．60±8234．85)次增至(55．73±5．05)次／min(P<0．05)、(78934．00±7194．21)次(P<0．01)。≥2s的长R-R间期由(2．79±1．54)s缩短至(2．22±1.17)s(P<0．05)、长R-R间期发作次数由(16．60±12．70)次减少至(5．10±5．38)次(P<0．01)。11例有持续较长时间的交界区逸搏心律者，其中7例交界区逸搏心律消失。结论黄连素与钙剂伍用对窦房结功能改善有一定作用，且无明显副作用。

The effects of berberine combination with calcium gluconate on sick sinus syndrome

Objective:To observe the therapy effects of berberine combination with calciumgluconate on sick sinus syndrome (SSS). Method:Twenty one patients of SSS have been treated by berberine combination with calciumgluconate for 8-10 days. Before and after treatment ,the longest sinus interval (LSR-R),the shortest sinus interval (SSR-R),24 h mean heart rate (MHR),24 h total heart beats (THR),the long pause (LR-R),the frequenclas of the long pause (FLR-R) have been measured respectively by 24 h Holter monitoring (DCG).Result: Before and after treatment, the values of LSR-R ,SSR-R,MHR, THR, LR-R,FLR-R are (1.86 ± 0.42) vs(1.67±0.63) s(P ＜0. 05), (0. 76±0.15) vs (0.66±0.10) s(P ＜0. 01), (53. 20±5. 63) vs (55.73±5.05) bm/min ( P ＜0.05),(73 974.60±8 234.85) vs (78 934.00±7 194.21) bm ( P ＜0.01),LR-R (2.79±1.54) vs (2.22±1.17) s (P ＜0.05),FLR-R (16.60±12.74) vs (5.10±5.38) bm (P ＜0.01) respectively.Conclusion: Berberine combination with calciun gluconate may improve sinus node performance in sick sinus syndrome and has not obvious side effects.