2型糖尿病患者颈动脉硬化斑块形成的相关因素分析

目的 探讨2型糖尿病患者颈动脉硬化斑块形成的相关因素.方法 123例2型糖尿病患者,根据颈动脉彩色超声结果分为颈动脉无硬化斑块组、颈动脉硬化斑块组,分别检测各组血清C反应蛋白、空腹血糖、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、血浆致动脉硬化指数、血尿酸、血肌酐,并记录年龄、糖尿病病程、体重指数、收缩压、舒张压、脉压差、吸烟史、高血压史、微血管并发症、颈动脉内膜厚度等指标,进行统计学处理.结果 颈动脉硬化斑块组中年龄(P<0.01)、C反应蛋白(P<0.05)、颈动脉内膜厚度(P<0.01)以及微血管并发症发生率(P<0.05)均比颈动脉无硬化斑块组显著增高,差别均有统计学意义.Logistic回归分析显示,颈动脉内膜厚度与颈动脉硬化斑块形成独立相关(P<0.05).结论 2型糖尿病患者颈动脉硬化斑块形成与颈动脉内膜厚度、年龄、C反应蛋白等多因素有关,颈动脉内膜厚度增加是颈动脉硬化斑块形成的危险因素,颈动脉硬化斑块形成的同时微血管并发症的发生率增加.

Factor Analysis of Carotid Angiosclerosis Plaque in Type 2 Diabetics

Aim To discuss the correlation factor of carotid angiosclerosis plaque in the patients with type 2 dia-betes mellitus (T2DM).Methods 123 cases of patients with T2DM, including non-carotid angiosclerosis plaque and carotid angiosclerosis plaque, were explored by color ultrasonoscope.The physical examinations included measurement of age, diabetes course, body mass index, blood pressure, smoking history, hypertension history, microangiopathy, carotid intima-media thickness, etc.Laboratory tests included serum C-reactive protein (CRP), fasting blood glucose, total cho-lesterol, triglycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol, atherogenic index of plas-ma, uric acid and serum creatinine.Results The levels of serum CRP (P<0.05), age (P<0.01), carotid intima-media thickness (P<0.01) and microangiopathy incidence (P<0.05) in angiosclerosis plaque group were higher than those in non-angiosclerosis plaque group.Stepwise regression analysis of relative factors for carotid angiosclerosis plaque showed that only the carotid intima-media thickness was significantly associated with the carotid angiosclerosis plaque(P<0.05).Conclusions Carotid angiosclerosis plaquemay be related to carotid intima-media thickness, age and CRP in the patients with T2DM.Carotid intima-media thickness may be a risk factor of carotid angiosclerosis plaque.Micrangi-um complication incidence will be raised accom panying with the formation of carotid angiosclerosis plaque.