保心包贴膜对稳定型心绞痛患者血浆内皮素和一氧化氮水平的影响

目的 研究保心包贴膜对稳定型心绞痛（SAP）患血浆内皮素（ET）和一氧化氮（NO）水平的影响。方法 76例SAP患随机单盲分为保心包组和硝酸异山梨酯组，分别给予保心包贴膜外敷心前区，每片4d(首次2片），共6片20d；硝酸异山梨酯10mg，每日3次，po。观察治疗前后血浆ET和NO水平。结果 SAP患治疗前血浆ET和NO水平分别显高于和低于正常对照组（均P＜0．01）；治疗后保心包组和硝酸异山梨酯组ET和NO代谢失衡均显改善，但以保心包组改善更为显（P＜0．05）。结论 保心包贴膜显改善SAP患ET和NO的代谢失衡，可能是其有效缓解心绞痛的机理之一。

Effect of baoxinbao film on plasma endothelin and nitric oxide levels in patients with stable angina pectoris

Aim To study the effect of Baoxinbao film on endothelin(ET) and nitric oxide(NO) secretion in patients with stable angina pectoris(SAP).Methods 76 patients with SAP were randomly divided into two groups, with 40 cases in the baoxinbao group plastered with baoxinbao film and 36 cases in the isosorbide dinitrate group receiving isosorbide dinitrate. The levels of plasma ET and NO before and after treatment were observed. Results The concentrations of plasma ET were increased and plasma NO reduced significantly in the SAP patients respectively, as compared with those in the control group(all P<0.01).After treatment the metabolic imbalance of ET and NO was improved markedly in both Baoxinbao and isosorbide groups(P<0.05 , P<0.01),but the imbalance of ET and NO in the Baoxinbao group was improved more obviously than that in the isosorbide group(P<0.05). Conclusion Baoxinbao film can obviously improve the metabolic imbalance of ET and NO secretion,which results in the effective alleviation of angina pectoris in patients with SAP.