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Effects of proteolytic degradation products of human fibrinogen and of human factor VIII on platelet aggregation and vascular permeability |
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| Authors: | J. Stachurska, S. Lopaciuk, B. Gerdin, T. Saldeen, A. Koro cik,M. Kope&#x |
| Affiliation: | a Department of Biochemistry, Institute of Rheumatology, Laboratory of Clinical Biochemistry, Institute of Haematology, Warsaw, Poland b Institute of Forensic Medicine, University of Uppsala, Sweden c Department of Radiobiology and Health Protection, Institute of Nuclear Research, Warsaw, Poland |
| Abstract: | Products of proteolysis of highly purified preparations of human fibrinogen (FDP) and of human factor VIII (VIII-DP) by plasmin were compared with respect to their ability to inhibit platelet aggregation and to enhance the permeability of rat skin microvasculature. Low molecular weight dialysable FDP (LMW-FDP, m. w. under 2754) induced complete inhibition of platelet aggregation in PRP at concentrations of and above 2. 5 mg/ml. Slight or very pronounced increase in skin microvasculature permeability was observed at LMW-FDP doses of 10 μg and 78 μg, respectively. In contrast, the whole digest of factor VIII as well as LMW-VIII-DP appeared inactive. Unfractionated digests of fibrinogen and fibrin formed either by thrombin of Defibrase exhibited the same antiaggregating potency. |
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