| 乙酰天麻素对血管平滑肌的解痉作用 |
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| 引用本文： | 李惠兰,苏芹,向建鸣,张子昭,莫云强.乙酰天麻素对血管平滑肌的解痉作用[J].药学学报,1986,21(7):539-541. |
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| 作者姓名： | 李惠兰 苏芹 向建鸣 张子昭 莫云强 |
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| 作者单位： | 昆明医学院药理教研组
(李惠兰，苏芹，向建鸣，张子昭)，昆明制药厂(莫云强) |
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| 摘 要： | 天麻属兰科植物,近年来从天麻中提出一个有效成分天麻素,经实验及临床观察认为是安全有效的镇静药。对神经衰弱,血管神经性头痛等可使症状减轻或消除。昆明制药厂对天麻素的结构进行了改造,合成了一系列的衍生物,其中乙酰天麻素(acetagastrodine,G2)作用比天麻素强,本文研究乙酰天麻素对血管平滑肌的影响。
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| 关 键 词： | 解痉药 乙酰天麻素 罂粟碱 |
| 收稿时间： | 1985-07-29 |
ANTISPASMODIC EFFECT OF ACETAGASTRODINE ON VASCULAR SMOOTH MUSCLE |
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| LI Hui-lan,SU Oin,XIANG Jian-Ming,ZHANG Zi-zhao and MO Yun-Qiang.ANTISPASMODIC EFFECT OF ACETAGASTRODINE ON VASCULAR SMOOTH MUSCLE[J].Acta Pharmaceutica Sinica,1986,21(7):539-541. |
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| Authors: | LI Hui-lan SU Oin XIANG Jian-Ming ZHANG Zi-zhao and MO Yun-Qiang |
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| Abstract: | Acetagastrodine is a derivative of gastrodine.The consistent contraction of the spiral strips of bovine Willis arteries caused by 5-HT(10-6M) was inhibited by both acetagastrodine and papaverine, the IC50 were 995±300 μg/ml and 161±71 μg/ml, respectively. The striking contraction caused by high conentration of potassium was also antagonized by acetagasstrodine and papaverine, the IC50 were 31. 53±10 . 5μg/ml and 35.18±16.6 μg/ml, respectivelyy.The strong contraction of spiral strips of rabbit aorta induced by noradrenaline 0.1μg/ml wes antagonized by acetagastrodine. The relaxing effect of aeetagastrodine on bovine Willis arteries was stronger then on rebbit erteries. |
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| Keywords: | Antispasmodic Acetagastrodine Pepaverine |
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