CYTOPHAGIC PANNlCULITIS |
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| Authors: | L. M. MARCH J. WEBB R. P. ECKSTEIN |
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| Affiliation: | NH&MRC Scholar, The Sydney University Departments of Medicine &Rheumatology, Royal North Shore Hospital, NSW;Senior Staff Rheumatologist, The Sydney University Department of Rheumatology, Royal North Shore Hospital, NSW;Staff Histopathologist, Dept Anatomical Pathology, Royal North Shore Hospital, NSW |
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| Abstract: | Abstract A 60 year old woman developed generalised erythema nodosum-like lesions together with hectic fever, lymphadenopathy, and hepatitis. Biopsies revealed lobular panniculitis with a benign histiocytic infiltrate and prominent phagocytosis in subcutaneous sites, lymph nodes, and bone marrow. All immunological, serological, and culture studies were negative, apart from throat isolation of herpes simplex. The patient responded to high-dose corticosteroids. The case illustrates the differential diagnosis of lobular panniculitis, with histiocytic infiltrate and cytophagocytosis. These combined features are consistent with the recently described syndromes of cytophagic panniculitis and virus-associated hemophagocytic syndrome. |
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| Keywords: | Lobular panniculitis histiocytic erythrophagocytosis cytophagic panniculitis virus-associated hemophagocytic syndrome. |
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